Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis

PURPOSE: To understand the effects of glutathione (GSH)-deficiency on genetic processes that regulate lens homeostasis and prevent cataractogenesis. METHODS: The transcriptome of lens epithelia and fiber cells was obtained from C57BL/6 LEGSKO (lens GSH-synthesis knockout) and buthionine sulfoximine...

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Detalles Bibliográficos
Autores principales: Whitson, Jeremy A., Zhang, Xiang, Medvedovic, Mario, Chen, Jenny, Wei, Zongbo, Monnier, Vincent M., Fan, Xingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Lens
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444549/
https://www.ncbi.nlm.nih.gov/pubmed/28525556
http://dx.doi.org/10.1167/iovs.16-21398

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