Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

Glioblastoma cells feature mammalian target of rapamycin (mTOR) up-regulation which relates to a variety of effects such as: lower survival, higher infiltration, high stemness and radio- and chemo-resistance. Recently, it was demonstrated that mTOR may produce a gene shift leading to altered protein...

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Detalles Bibliográficos
Autores principales: Ferrucci, Michela, Biagioni, Francesca, Lenzi, Paola, Gambardella, Stefano, Ferese, Rosangela, Calierno, Maria Teresa, Falleni, Alessandra, Grimaldi, Alfonso, Frati, Alessandro, Esposito, Vincenzo, Limatola, Cristina, Fornai, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444688/
https://www.ncbi.nlm.nih.gov/pubmed/28418837
http://dx.doi.org/10.18632/oncotarget.15906

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