Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models

PURPOSE: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a single agent and combined with radiotherapy (RT)...

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Detalles Bibliográficos
Autores principales: Gravina, Giovanni Luca, Mancini, Andrea, Mattei, Claudia, Vitale, Flora, Marampon, Francesco, Colapietro, Alessandro, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Di Cesare, Ernesto, Fox, Judith A., Festuccia, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444710/
https://www.ncbi.nlm.nih.gov/pubmed/28415741
http://dx.doi.org/10.18632/oncotarget.16168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444710/
https://www.ncbi.nlm.nih.gov/pubmed/28415741
http://dx.doi.org/10.18632/oncotarget.16168

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