Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs

DNA methyltransferase 3A (DNMT3A) mutations occurred in 18%~23% of acute myeloid leukemia (AML) patients, and were considered to be an adverse prognostic factor for adult de novo AML cases. However, the relevant molecular mechanism of the mutation in AML pathogenesis remains obscure. In this study,...

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Detalles Bibliográficos
Autores principales: Yang, Li, Liu, Ya’Nan, Zhang, Na, Ding, Xiao’Yi, Zhang, Wei, Shen, Ke’Feng, Huang, Liang, Zhou, Jian’Feng, Cui, Sen, Zhu, Zun’Min, Hu, Zheng, Xiao, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444751/
https://www.ncbi.nlm.nih.gov/pubmed/28418922
http://dx.doi.org/10.18632/oncotarget.16449

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