Cargando…
Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation
mTOR activation suppresses autophagy by phosphorylating ULK1 at S757 and suppressing its enzymatic activity. Here we report that feedback activation of mTOR in the PI-3 kinase pathway by two p70 S6 kinase (S6K1) inhibitors (PF-4708671 and A77 1726, the active metabolite of an immunosuppressive drug...
Autores principales: | Xu, Xiulong, Sun, §Jing, Song, Ruilong, Doscas, Michelle E., Williamson, Ashley J., Zhou, Jingsong, Sun, Jun, Jiao, Xinan, Liu, Xiufan, Li, Yi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444754/ https://www.ncbi.nlm.nih.gov/pubmed/28389629 http://dx.doi.org/10.18632/oncotarget.16737 |
Ejemplares similares
-
Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress()()
por: Doscas, Michelle E., et al.
Publicado: (2014) -
Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates
por: Sun, Jing, et al.
Publicado: (2018) -
The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
por: Kirsch, Bernhard M, et al.
Publicado: (2005) -
The active metabolite of leflunomide, A77-1726, increases proliferation of human synovial fibroblasts in presence of IL-1β
por: Magne, D, et al.
Publicado: (2004) -
Inhibition of porcine epidemic diarrhea virus (PEDV) replication by A77 1726 through targeting JAK and Src tyrosine kinases
por: Li, Xiaomei, et al.
Publicado: (2020)