Cargando…

Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016–2017 season

In the 2016–2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the...

Descripción completa

Detalles Bibliográficos
Autores principales: Noh, Ji Yun, Lim, Sooyeon, Song, Joon Young, Choi, Won Suk, Jeong, Hye Won, Heo, Jung Yeon, Lee, Jacob, Seo, Yu Bin, Lee, Jin-Soo, Wie, Seong Heon, Kim, Young Keun, Park, Kyung Hwa, Jung, Sook-In, Kim, Shin Woo, Lee, Sun Hee, Lee, Han Sol, Yoon, Young Hoon, Cheong, Hee Jin, Kim, Woo Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444786/
https://www.ncbi.nlm.nih.gov/pubmed/28542417
http://dx.doi.org/10.1371/journal.pone.0178010
Descripción
Sumario:In the 2016–2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147.2 to 6.4); -70.0% (95% CI, -212.0 to 7.4) in 19–64 years and 4.3% (95% CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016–2017 influenza season.