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Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer
Epidemiological studies have shown obesity to be linked with poorer outcomes in breast cancer patients. The molecular mechanisms responsible for the increased risk of invasive/metastatic disease with obesity are complex, but may include elevated levels of adipokines such as leptin. Using physiologic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444832/ https://www.ncbi.nlm.nih.gov/pubmed/28542577 http://dx.doi.org/10.1371/journal.pone.0178454 |