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Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
BACKGROUND: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. OBJECTIVE: To identify factors associated with CAD progression in patients undergoing sequential CCTA testi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia - SBC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444885/ https://www.ncbi.nlm.nih.gov/pubmed/28492738 http://dx.doi.org/10.5935/abc.20170049 |
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author | Camargo, Gabriel Cordeiro Rothstein, Tamara Derenne, Maria Eduarda Sabioni, Leticia Lima, João A. C. Lima, Ronaldo de Souza Leão Gottlieb, Ilan |
author_facet | Camargo, Gabriel Cordeiro Rothstein, Tamara Derenne, Maria Eduarda Sabioni, Leticia Lima, João A. C. Lima, Ronaldo de Souza Leão Gottlieb, Ilan |
author_sort | Camargo, Gabriel Cordeiro |
collection | PubMed |
description | BACKGROUND: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. OBJECTIVE: To identify factors associated with CAD progression in patients undergoing sequential CCTA testing. METHODS: We retrospectively analyzed 384 consecutive patients who had at least two CCTA studies between December 2005 and March 2013. Due to limitations in the quantification of CAD progression, we excluded patients who had undergone surgical revascularization previously or percutaneous coronary intervention (PCI) between studies. CAD progression was defined as any increase in the adapted segment stenosis score (calculated using the number of diseased segments and stenosis severity) in all coronary segments without stent (in-stent restenosis was excluded from the analysis). Stepwise logistic regression was used to assess variables associated with CAD progression. RESULTS: From a final population of 234 patients, a total of 117 (50%) had CAD progression. In a model accounting for major CAD risk factors and other baseline characteristics, only age (odds ratio [OR] 1.04, 95% confidence interval [95%CI] 1.01-1.07), interstudy interval (OR 1.03, 95%CI 1.01-1.04), and past PCI (OR 3.66, 95%CI 1.77-7.55) showed an independent relationship with CAD progression. CONCLUSIONS: A history of PCI with stent placement was independently associated with a 3.7-fold increase in the odds of CAD progression, excluding in-stent restenosis. Age and interstudy interval were also independent predictors of progression. |
format | Online Article Text |
id | pubmed-5444885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54448852017-05-31 Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography Camargo, Gabriel Cordeiro Rothstein, Tamara Derenne, Maria Eduarda Sabioni, Leticia Lima, João A. C. Lima, Ronaldo de Souza Leão Gottlieb, Ilan Arq Bras Cardiol Original Articles BACKGROUND: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. OBJECTIVE: To identify factors associated with CAD progression in patients undergoing sequential CCTA testing. METHODS: We retrospectively analyzed 384 consecutive patients who had at least two CCTA studies between December 2005 and March 2013. Due to limitations in the quantification of CAD progression, we excluded patients who had undergone surgical revascularization previously or percutaneous coronary intervention (PCI) between studies. CAD progression was defined as any increase in the adapted segment stenosis score (calculated using the number of diseased segments and stenosis severity) in all coronary segments without stent (in-stent restenosis was excluded from the analysis). Stepwise logistic regression was used to assess variables associated with CAD progression. RESULTS: From a final population of 234 patients, a total of 117 (50%) had CAD progression. In a model accounting for major CAD risk factors and other baseline characteristics, only age (odds ratio [OR] 1.04, 95% confidence interval [95%CI] 1.01-1.07), interstudy interval (OR 1.03, 95%CI 1.01-1.04), and past PCI (OR 3.66, 95%CI 1.77-7.55) showed an independent relationship with CAD progression. CONCLUSIONS: A history of PCI with stent placement was independently associated with a 3.7-fold increase in the odds of CAD progression, excluding in-stent restenosis. Age and interstudy interval were also independent predictors of progression. Sociedade Brasileira de Cardiologia - SBC 2017-05 /pmc/articles/PMC5444885/ /pubmed/28492738 http://dx.doi.org/10.5935/abc.20170049 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Camargo, Gabriel Cordeiro Rothstein, Tamara Derenne, Maria Eduarda Sabioni, Leticia Lima, João A. C. Lima, Ronaldo de Souza Leão Gottlieb, Ilan Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography |
title | Factors Associated With Coronary Artery Disease Progression Assessed
By Serial Coronary Computed Tomography Angiography |
title_full | Factors Associated With Coronary Artery Disease Progression Assessed
By Serial Coronary Computed Tomography Angiography |
title_fullStr | Factors Associated With Coronary Artery Disease Progression Assessed
By Serial Coronary Computed Tomography Angiography |
title_full_unstemmed | Factors Associated With Coronary Artery Disease Progression Assessed
By Serial Coronary Computed Tomography Angiography |
title_short | Factors Associated With Coronary Artery Disease Progression Assessed
By Serial Coronary Computed Tomography Angiography |
title_sort | factors associated with coronary artery disease progression assessed
by serial coronary computed tomography angiography |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444885/ https://www.ncbi.nlm.nih.gov/pubmed/28492738 http://dx.doi.org/10.5935/abc.20170049 |
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