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Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways
Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Anti-Cancer Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444925/ https://www.ncbi.nlm.nih.gov/pubmed/28607804 http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0033 |
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author | Nwabo Kamdje, Armel Herve Kamga, Paul Takam Simo, Richard Tagne Vecchio, Lorella Seke Etet, Paul Faustin Muller, Jean Marc Bassi, Giulio Lukong, Erique Goel, Raghuveera Kumar Amvene, Jeremie Mbo Krampera, Mauro |
author_facet | Nwabo Kamdje, Armel Herve Kamga, Paul Takam Simo, Richard Tagne Vecchio, Lorella Seke Etet, Paul Faustin Muller, Jean Marc Bassi, Giulio Lukong, Erique Goel, Raghuveera Kumar Amvene, Jeremie Mbo Krampera, Mauro |
author_sort | Nwabo Kamdje, Armel Herve |
collection | PubMed |
description | Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like " wounds that do not heal.” In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. |
format | Online Article Text |
id | pubmed-5444925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Chinese Anti-Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-54449252017-06-12 Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways Nwabo Kamdje, Armel Herve Kamga, Paul Takam Simo, Richard Tagne Vecchio, Lorella Seke Etet, Paul Faustin Muller, Jean Marc Bassi, Giulio Lukong, Erique Goel, Raghuveera Kumar Amvene, Jeremie Mbo Krampera, Mauro Cancer Biol Med Review Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like " wounds that do not heal.” In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. Chinese Anti-Cancer Association 2017-05 /pmc/articles/PMC5444925/ /pubmed/28607804 http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0033 Text en Copyright 2017 Cancer Biology & Medicine http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Review Nwabo Kamdje, Armel Herve Kamga, Paul Takam Simo, Richard Tagne Vecchio, Lorella Seke Etet, Paul Faustin Muller, Jean Marc Bassi, Giulio Lukong, Erique Goel, Raghuveera Kumar Amvene, Jeremie Mbo Krampera, Mauro Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
title | Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
title_full | Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
title_fullStr | Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
title_full_unstemmed | Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
title_short | Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
title_sort | mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444925/ https://www.ncbi.nlm.nih.gov/pubmed/28607804 http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0033 |
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