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Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates

Host recognition and immune-mediated foreign body response (FBR) to biomaterials can compromise the performance of implanted medical devices. To identify key cell and cytokine targets, here we perform in-depth systems analysis of innate and adaptive immune system responses to implanted biomaterials...

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Autores principales: Doloff, Joshua C., Veiseh, Omid, Vegas, Arturo J., Tam, Hok Hei, Farah, Shady, Ma, Minglin, Li, Jie, Bader, Andrew, Chiu, Alan, Sadraei, Atieh, Aresta-Dasilva, Stephanie, Griffin, Marissa, Jhunjhunwala, Siddharth, Webber, Matthew, Siebert, Sean, Tang, Katherine, Chen, Michael, Langan, Erin, Dholokia, Nimit, Thakrar, Raj, Qi, Meirigeng, Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445003/
https://www.ncbi.nlm.nih.gov/pubmed/28319612
http://dx.doi.org/10.1038/nmat4866
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author Doloff, Joshua C.
Veiseh, Omid
Vegas, Arturo J.
Tam, Hok Hei
Farah, Shady
Ma, Minglin
Li, Jie
Bader, Andrew
Chiu, Alan
Sadraei, Atieh
Aresta-Dasilva, Stephanie
Griffin, Marissa
Jhunjhunwala, Siddharth
Webber, Matthew
Siebert, Sean
Tang, Katherine
Chen, Michael
Langan, Erin
Dholokia, Nimit
Thakrar, Raj
Qi, Meirigeng
Oberholzer, Jose
Greiner, Dale L.
Langer, Robert
Anderson, Daniel G.
author_facet Doloff, Joshua C.
Veiseh, Omid
Vegas, Arturo J.
Tam, Hok Hei
Farah, Shady
Ma, Minglin
Li, Jie
Bader, Andrew
Chiu, Alan
Sadraei, Atieh
Aresta-Dasilva, Stephanie
Griffin, Marissa
Jhunjhunwala, Siddharth
Webber, Matthew
Siebert, Sean
Tang, Katherine
Chen, Michael
Langan, Erin
Dholokia, Nimit
Thakrar, Raj
Qi, Meirigeng
Oberholzer, Jose
Greiner, Dale L.
Langer, Robert
Anderson, Daniel G.
author_sort Doloff, Joshua C.
collection PubMed
description Host recognition and immune-mediated foreign body response (FBR) to biomaterials can compromise the performance of implanted medical devices. To identify key cell and cytokine targets, here we perform in-depth systems analysis of innate and adaptive immune system responses to implanted biomaterials in rodents and non-human primates. While macrophages are indispensable to the fibrotic cascade, surprisingly neutrophils and complement are not. Macrophages, via CXCL13, lead to downstream B cell recruitment, which further potentiated fibrosis, as confirmed by B cell knock out and CXCL13 neutralization. Interestingly, Colony Stimulating Factor-1 Receptor (CSF1R) is significantly increased following implantation of multiple biomaterial classes: ceramic, polymer, and hydrogel. Its inhibition, like macrophage depletion, leads to complete loss of fibrosis, but spares other macrophage functions such as wound healing, ROS production, and phagocytosis. Our results indicate targeting CSF1R may allow for a more selective method of fibrosis inhibition, and improve biomaterial biocompatibility without the need for broad immunosuppression.
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spelling pubmed-54450032017-09-20 Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates Doloff, Joshua C. Veiseh, Omid Vegas, Arturo J. Tam, Hok Hei Farah, Shady Ma, Minglin Li, Jie Bader, Andrew Chiu, Alan Sadraei, Atieh Aresta-Dasilva, Stephanie Griffin, Marissa Jhunjhunwala, Siddharth Webber, Matthew Siebert, Sean Tang, Katherine Chen, Michael Langan, Erin Dholokia, Nimit Thakrar, Raj Qi, Meirigeng Oberholzer, Jose Greiner, Dale L. Langer, Robert Anderson, Daniel G. Nat Mater Article Host recognition and immune-mediated foreign body response (FBR) to biomaterials can compromise the performance of implanted medical devices. To identify key cell and cytokine targets, here we perform in-depth systems analysis of innate and adaptive immune system responses to implanted biomaterials in rodents and non-human primates. While macrophages are indispensable to the fibrotic cascade, surprisingly neutrophils and complement are not. Macrophages, via CXCL13, lead to downstream B cell recruitment, which further potentiated fibrosis, as confirmed by B cell knock out and CXCL13 neutralization. Interestingly, Colony Stimulating Factor-1 Receptor (CSF1R) is significantly increased following implantation of multiple biomaterial classes: ceramic, polymer, and hydrogel. Its inhibition, like macrophage depletion, leads to complete loss of fibrosis, but spares other macrophage functions such as wound healing, ROS production, and phagocytosis. Our results indicate targeting CSF1R may allow for a more selective method of fibrosis inhibition, and improve biomaterial biocompatibility without the need for broad immunosuppression. 2017-03-20 2017-06 /pmc/articles/PMC5445003/ /pubmed/28319612 http://dx.doi.org/10.1038/nmat4866 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Doloff, Joshua C.
Veiseh, Omid
Vegas, Arturo J.
Tam, Hok Hei
Farah, Shady
Ma, Minglin
Li, Jie
Bader, Andrew
Chiu, Alan
Sadraei, Atieh
Aresta-Dasilva, Stephanie
Griffin, Marissa
Jhunjhunwala, Siddharth
Webber, Matthew
Siebert, Sean
Tang, Katherine
Chen, Michael
Langan, Erin
Dholokia, Nimit
Thakrar, Raj
Qi, Meirigeng
Oberholzer, Jose
Greiner, Dale L.
Langer, Robert
Anderson, Daniel G.
Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
title Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
title_full Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
title_fullStr Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
title_full_unstemmed Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
title_short Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
title_sort colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445003/
https://www.ncbi.nlm.nih.gov/pubmed/28319612
http://dx.doi.org/10.1038/nmat4866
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