Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have ad...

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Autores principales: Pereira, Leonn Mendes Soares, Gomes, Samara Tatielle Monteiro, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445144/
https://www.ncbi.nlm.nih.gov/pubmed/28603524
http://dx.doi.org/10.3389/fimmu.2017.00605
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author Pereira, Leonn Mendes Soares
Gomes, Samara Tatielle Monteiro
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosário
author_facet Pereira, Leonn Mendes Soares
Gomes, Samara Tatielle Monteiro
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosário
author_sort Pereira, Leonn Mendes Soares
collection PubMed
description The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance.
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spelling pubmed-54451442017-06-09 Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis Pereira, Leonn Mendes Soares Gomes, Samara Tatielle Monteiro Ishak, Ricardo Vallinoto, Antonio Carlos Rosário Front Immunol Immunology The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance. Frontiers Media S.A. 2017-05-26 /pmc/articles/PMC5445144/ /pubmed/28603524 http://dx.doi.org/10.3389/fimmu.2017.00605 Text en Copyright © 2017 Pereira, Gomes, Ishak and Vallinoto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pereira, Leonn Mendes Soares
Gomes, Samara Tatielle Monteiro
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosário
Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
title Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
title_full Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
title_fullStr Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
title_full_unstemmed Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
title_short Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
title_sort regulatory t cell and forkhead box protein 3 as modulators of immune homeostasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445144/
https://www.ncbi.nlm.nih.gov/pubmed/28603524
http://dx.doi.org/10.3389/fimmu.2017.00605
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