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C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy

BACKGROUND: Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system. In neuronal tumor cells DNA-damaging chemotherapeutic agents activate the transcription factor FOXO3 which regulates the formation of reactive...

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Detalles Bibliográficos
Autores principales:	Salcher, S., Hermann, M., Kiechl-Kohlendorfer, U., Ausserlechner, M. J., Obexer, P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445297/ https://www.ncbi.nlm.nih.gov/pubmed/28545464 http://dx.doi.org/10.1186/s12943-017-0661-4

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