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Tie2 as a novel key factor of microangiopathy in systemic sclerosis

BACKGROUND: The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth factor (VEGF), hypoxia, and inflammation, acts as an antagonist. Tie2 signallin...

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Detalles Bibliográficos
Autores principales:	Moritz, Falk, Schniering, Janine, Distler, Jörg H. W., Gay, Renate E., Gay, Steffen, Distler, Oliver, Maurer, Britta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445339/ https://www.ncbi.nlm.nih.gov/pubmed/28545512 http://dx.doi.org/10.1186/s13075-017-1304-2

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