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Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity

BACKGROUND: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease and there is no related literature concerning psychiatric symptoms in SAPHO patients. Thus, we believe that this will be the first paper to explore the episode and the neurobiological basis of depression s...

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Autores principales: Lu, Jie, Duan, Yanping, Zuo, Zhentao, Xu, Wenrui, Zhang, Xuewei, Li, Chen, Xue, Rong, Lu, Hanzhang, Zhang, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445372/
https://www.ncbi.nlm.nih.gov/pubmed/28545486
http://dx.doi.org/10.1186/s13023-017-0658-5
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author Lu, Jie
Duan, Yanping
Zuo, Zhentao
Xu, Wenrui
Zhang, Xuewei
Li, Chen
Xue, Rong
Lu, Hanzhang
Zhang, Weihong
author_facet Lu, Jie
Duan, Yanping
Zuo, Zhentao
Xu, Wenrui
Zhang, Xuewei
Li, Chen
Xue, Rong
Lu, Hanzhang
Zhang, Weihong
author_sort Lu, Jie
collection PubMed
description BACKGROUND: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease and there is no related literature concerning psychiatric symptoms in SAPHO patients. Thus, we believe that this will be the first paper to explore the episode and the neurobiological basis of depression symptoms in SAPHO patients using resting state functional magnetic resonance imaging (rs-fMRI). Twenty-eight SAPHO patients and fifteen age- and gender- matched normal controls (NC) were consecutively submitted to psychiatric evaluation and rs-fMRI scanning. RESULTS: 46.2% (13/28) of SAPHO patients were diagnosed as depression. The local spontaneous activity study showed that depressed SAPHO (D-SAPHO) patients had decreased amplitude of low-frequency fluctuation (ALFF) in the bilateral ventrolateral prefrontal cortex (VLPFC, attributed to the anatomical structures of Brodmann’s area 47, 45 and 44) and right dorsolateral prefrontal cortex (DLPFC, attributed to the anatomical structures of Brodmann’s area 8, 9 and 46), increased ALFF in the bilateral middle temporal gyrus, when compared to non-depressed SAPHO (ND-SAPHO) patients. The functional connectivity (FC) study disclosed that D-SAPHO patients had an increased FC in the anterior portions of default mode network (DMN) (the bilateral inferior frontal cortex, anterior cingulate cortex and insula cortex), and a decreased FC in the posterior areas of DMN (left middle occipital cortex), when compared to ND-SAPHO patients. Furthermore, correlation analysis revealed that both ALFF and FC values were significantly correlated with depression scores of SAPHO patients. CONCLUSION: These results prompt us to understand the underlying pathophysiological mechanism of depression in SAPHO syndrome, and demonstrate that abnormal brain functional areas may serve as effective biological indicators to monitor depression in the future. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13023-017-0658-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-54453722017-05-30 Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity Lu, Jie Duan, Yanping Zuo, Zhentao Xu, Wenrui Zhang, Xuewei Li, Chen Xue, Rong Lu, Hanzhang Zhang, Weihong Orphanet J Rare Dis Research BACKGROUND: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease and there is no related literature concerning psychiatric symptoms in SAPHO patients. Thus, we believe that this will be the first paper to explore the episode and the neurobiological basis of depression symptoms in SAPHO patients using resting state functional magnetic resonance imaging (rs-fMRI). Twenty-eight SAPHO patients and fifteen age- and gender- matched normal controls (NC) were consecutively submitted to psychiatric evaluation and rs-fMRI scanning. RESULTS: 46.2% (13/28) of SAPHO patients were diagnosed as depression. The local spontaneous activity study showed that depressed SAPHO (D-SAPHO) patients had decreased amplitude of low-frequency fluctuation (ALFF) in the bilateral ventrolateral prefrontal cortex (VLPFC, attributed to the anatomical structures of Brodmann’s area 47, 45 and 44) and right dorsolateral prefrontal cortex (DLPFC, attributed to the anatomical structures of Brodmann’s area 8, 9 and 46), increased ALFF in the bilateral middle temporal gyrus, when compared to non-depressed SAPHO (ND-SAPHO) patients. The functional connectivity (FC) study disclosed that D-SAPHO patients had an increased FC in the anterior portions of default mode network (DMN) (the bilateral inferior frontal cortex, anterior cingulate cortex and insula cortex), and a decreased FC in the posterior areas of DMN (left middle occipital cortex), when compared to ND-SAPHO patients. Furthermore, correlation analysis revealed that both ALFF and FC values were significantly correlated with depression scores of SAPHO patients. CONCLUSION: These results prompt us to understand the underlying pathophysiological mechanism of depression in SAPHO syndrome, and demonstrate that abnormal brain functional areas may serve as effective biological indicators to monitor depression in the future. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13023-017-0658-5) contains supplementary material, which is available to authorized users. BioMed Central 2017-05-25 /pmc/articles/PMC5445372/ /pubmed/28545486 http://dx.doi.org/10.1186/s13023-017-0658-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Lu, Jie
Duan, Yanping
Zuo, Zhentao
Xu, Wenrui
Zhang, Xuewei
Li, Chen
Xue, Rong
Lu, Hanzhang
Zhang, Weihong
Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity
title Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity
title_full Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity
title_fullStr Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity
title_full_unstemmed Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity
title_short Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity
title_sort depression in patients with sapho syndrome and its relationship with brain activity and connectivity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445372/
https://www.ncbi.nlm.nih.gov/pubmed/28545486
http://dx.doi.org/10.1186/s13023-017-0658-5
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