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Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is...

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Autores principales: Papa, Anna, Tsergouli, Katerina, Tsioka, Katerina, Mirazimi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445422/
https://www.ncbi.nlm.nih.gov/pubmed/28603698
http://dx.doi.org/10.3389/fcimb.2017.00213
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author Papa, Anna
Tsergouli, Katerina
Tsioka, Katerina
Mirazimi, Ali
author_facet Papa, Anna
Tsergouli, Katerina
Tsioka, Katerina
Mirazimi, Ali
author_sort Papa, Anna
collection PubMed
description Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment required for CCHFV studies. Among ticks, Hyalomma spp. are considered the most competent virus vectors. CCHFV evades the tick immune response, and following its replication in the lining of the tick's midgut, it is disseminated by the hemolymph in the salivary glands and reproductive organs. The introduction of salivary gland secretions into the host cells is the major route via which CCHFV enters the host. Following an initial amplification at the site of inoculation, the virus is spread to the target organs. Apoptosis is induced via both intrinsic and extrinsic pathways. Genetic factors and immune status of the host may affect the release of cytokines which play a major role in disease progression and outcome. It is expected that the use of new technology of metabolomics, transcriptomics and proteomics will lead to improved understanding of CCHFV-host interactions and identify potential targets for blocking the CCHFV transmission.
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spelling pubmed-54454222017-06-09 Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions Papa, Anna Tsergouli, Katerina Tsioka, Katerina Mirazimi, Ali Front Cell Infect Microbiol Microbiology Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment required for CCHFV studies. Among ticks, Hyalomma spp. are considered the most competent virus vectors. CCHFV evades the tick immune response, and following its replication in the lining of the tick's midgut, it is disseminated by the hemolymph in the salivary glands and reproductive organs. The introduction of salivary gland secretions into the host cells is the major route via which CCHFV enters the host. Following an initial amplification at the site of inoculation, the virus is spread to the target organs. Apoptosis is induced via both intrinsic and extrinsic pathways. Genetic factors and immune status of the host may affect the release of cytokines which play a major role in disease progression and outcome. It is expected that the use of new technology of metabolomics, transcriptomics and proteomics will lead to improved understanding of CCHFV-host interactions and identify potential targets for blocking the CCHFV transmission. Frontiers Media S.A. 2017-05-26 /pmc/articles/PMC5445422/ /pubmed/28603698 http://dx.doi.org/10.3389/fcimb.2017.00213 Text en Copyright © 2017 Papa, Tsergouli, Tsioka and Mirazimi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Papa, Anna
Tsergouli, Katerina
Tsioka, Katerina
Mirazimi, Ali
Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions
title Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions
title_full Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions
title_fullStr Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions
title_full_unstemmed Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions
title_short Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions
title_sort crimean-congo hemorrhagic fever: tick-host-virus interactions
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445422/
https://www.ncbi.nlm.nih.gov/pubmed/28603698
http://dx.doi.org/10.3389/fcimb.2017.00213
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