Cargando…

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt(Mt2) by biapenem and tebipenem

BACKGROUND: The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical transpeptidases (L,D-transpeptidases) that generate 3 → 3 linkages in bacterial pep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bianchet, Mario A., Pan, Ying H., Basta, Leighanne A. Brammer, Saavedra, Harry, Lloyd, Evan P., Kumar, Pankaj, Mattoo, Rohini, Townsend, Craig A., Lamichhane, Gyanu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445500/ https://www.ncbi.nlm.nih.gov/pubmed/28545389 http://dx.doi.org/10.1186/s12858-017-0082-4

Ejemplares similares

Ldt(Mav2), a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems
por: Mattoo, Rohini, et al.
Publicado: (2017)

The Mycobacterium tuberculosis gene, ldt(Mt2), encodes a non-classical transpeptidase required for virulence and resistance to amoxicillin
por: Gupta, Radhika, et al.
Publicado: (2010)

Non-classical transpeptidases yield insight into new antibacterials
por: Kumar, Pankaj, et al.
Publicado: (2016)

Structure of Ldt(Mt2), an l,d-transpeptidase from Mycobacterium tuberculosis
por: Böth, Dominic, et al.
Publicado: (2013)

Targeting the Mycobacterium tuberculosis transpeptidase Ldt(Mt2) with cysteine-reactive inhibitors including ebselen
por: de Munnik, Mariska, et al.
Publicado: (2019)

A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase Ldt(Mt2)
por: de Munnik, Mariska, et al.
Publicado: (2019)

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase
por: Ahmad, Nazia, et al.
Publicado: (2022)

High-throughput screen with the l,d-transpeptidase Ldt(Mt2) of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors
por: de Munnik, Mariska, et al.
Publicado: (2023)

Protective Efficacy of BCG Overexpressing an L,D-Transpeptidase against M. tuberculosis Infection
por: Nolan, Scott T., et al.
Publicado: (2010)

1105. Population Pharmacokinetic Analyses for Tebipenem After the Administration of Tebipenem Pivoxil Hydrobromide
por: Ganesan, Harish, et al.
Publicado: (2021)

Biapenem Inactivation by B2 Metallo β-Lactamases: Energy Landscape of the Hydrolysis Reaction
por: Ackerman, Sharon H., et al.
Publicado: (2013)

Population Pharmacokinetic Analyses for Tebipenem after Oral Administration of Pro-Drug Tebipenem Pivoxil Hydrobromide
por: Ganesan, H., et al.
Publicado: (2023)

Zinc is an inhibitor of the LdtR transcriptional activator
por: Pagliai, Fernando A., et al.
Publicado: (2018)

Crystal structure of tebipenem pivoxil
por: Tang, Chao, et al.
Publicado: (2018)

PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration
por: Akashita, Gaku, et al.
Publicado: (2015)

Biapenem Inactivation by B2 Metallo β-Lactamases: Energy Landscape of the Post-Hydrolysis Reactions
por: Gatti, Domenico L.
Publicado: (2012)

Metabolomic Insights Into the Synergistic Effect of Biapenem in Combination With Xuebijing Injection Against Sepsis
por: Liu, Li-Wei, et al.
Publicado: (2020)

LdtR is a master regulator of gene expression in Liberibacter asiaticus
por: Pagliai, Fernando A., et al.
Publicado: (2017)

1432. Exploring Cell Wall Targets to Overcome Mycobacterium tuberculosis (Mtb): Ceftriaxone (CRO) Inhibits Ldt(Mt2), a Major Peptidoglycan (PG) Synthase
por: Nguyen, David C, et al.
Publicado: (2022)

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
por: Lucic, Anka, et al.
Publicado: (2022)

Identification of a Ligand Binding Pocket in LdtR from Liberibacter asiaticus
por: Pagliai, Fernando A., et al.
Publicado: (2015)

Biapenem versus meropenem in the treatment of bacterial infections: a multicenter, randomized, controlled clinical trial
por: Wang, Xiaohui, et al.
Publicado: (2013)

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury
por: Lee, Wonhwa, et al.
Publicado: (2020)

Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis
por: Pahuja, Isha, et al.
Publicado: (2023)

Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)
por: Romero-Leguizamón, César R., et al.
Publicado: (2019)

Diagnosis of Parkinson’s Disease by A Metabolomics-Based Laboratory-Developed Test (LDT)
por: Lokhov, Petr G., et al.
Publicado: (2020)

Plasticity in the Brainstem: Prenatal and Postnatal Experience Can Alter Laterodorsal Tegmental (LDT) Structure and Function
por: Kohlmeier, Kristi A., et al.
Publicado: (2020)

Purification and partial characterization of LdtP, a cell envelope modifying enzyme in Liberibacter asiaticus
por: Coyle, Janelle F., et al.
Publicado: (2018)

Pharmacokinetics of Oral Tebipenem Pivoxil Hydrobromide in Subjects with Various Degrees of Renal Impairment
por: Patel, Gina, et al.
Publicado: (2022)

Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi
por: Mylona, Elli, et al.
Publicado: (2021)

Bioequivalence of two oral formulations of tebipenem pivoxil hydrobromide in healthy subjects
por: Gupta, Vipul K., et al.
Publicado: (2022)

The Transcriptional Activator LdtR from ‘Candidatus Liberibacter asiaticus’ Mediates Osmotic Stress Tolerance
por: Pagliai, Fernando A., et al.
Publicado: (2014)

In vitro diagnostic medical device regulation (IVDR): the end of laboratory developed tests (LDT)?
por: Barberis, Massimo
Publicado: (2021)

1044. In vitro Activity of Tebipenem Against Relevant Clinical Isolates in the Presence of Pulmonary Surfactant
por: Arends, S J Ryan, et al.
Publicado: (2021)

Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection
por: Negatu, Dereje A., et al.
Publicado: (2023)

Stress Degradation Studies of Tebipenem and a Validated Stability-Indicating LC Method
por: Cielecka-Piontek, Judyta, et al.
Publicado: (2012)

Investigation of pneumonia-causing pathogenic organisms in children and the usefulness of tebipenem pivoxil for their treatment
por: Kuroki, Haruo, et al.
Publicado: (2010)

Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population
por: Chen, Weijie, et al.
Publicado: (2022)

ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia
por: Noël, F., et al.
Publicado: (2016)

Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity
por: Triboulet, Sébastien, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2adec9gcvcpj0ah1sgok75cckb