HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research

The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an approp...

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Autores principales: Furutani, Kazuharu, Tsumoto, Kunichika, Kurachi, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445586/
https://www.ncbi.nlm.nih.gov/pubmed/28649429
http://dx.doi.org/10.1038/s41540-016-0001-0
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author Furutani, Kazuharu
Tsumoto, Kunichika
Kurachi, Yoshihisa
author_facet Furutani, Kazuharu
Tsumoto, Kunichika
Kurachi, Yoshihisa
author_sort Furutani, Kazuharu
collection PubMed
description The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research.
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spelling pubmed-54455862017-06-23 HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research Furutani, Kazuharu Tsumoto, Kunichika Kurachi, Yoshihisa NPJ Syst Biol Appl Review Article The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research. Nature Publishing Group UK 2017-01-16 /pmc/articles/PMC5445586/ /pubmed/28649429 http://dx.doi.org/10.1038/s41540-016-0001-0 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Furutani, Kazuharu
Tsumoto, Kunichika
Kurachi, Yoshihisa
HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_full HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_fullStr HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_full_unstemmed HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_short HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_sort hd physiology project—japanese efforts to promote multilevel integrative systems biology and physiome research
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445586/
https://www.ncbi.nlm.nih.gov/pubmed/28649429
http://dx.doi.org/10.1038/s41540-016-0001-0
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