Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?

Parkinson’s disease (PD) is now considered to be a multisystemic disorder consequent on multineuropeptide dysfunction including dopaminergic, serotonergic, cholinergic, and noradrenergic systems. This multipeptide dysfunction leads to expression of a range of non-motor symptoms now known to be integ...

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Autores principales: Qamar, MA, Sauerbier, A, Politis, M, Carr, H, Loehrer, P A, Chaudhuri, K Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445592/
https://www.ncbi.nlm.nih.gov/pubmed/28649605
http://dx.doi.org/10.1038/s41531-016-0006-9
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author Qamar, MA
Sauerbier, A
Politis, M
Carr, H
Loehrer, P A
Chaudhuri, K Ray
author_facet Qamar, MA
Sauerbier, A
Politis, M
Carr, H
Loehrer, P A
Chaudhuri, K Ray
author_sort Qamar, MA
collection PubMed
description Parkinson’s disease (PD) is now considered to be a multisystemic disorder consequent on multineuropeptide dysfunction including dopaminergic, serotonergic, cholinergic, and noradrenergic systems. This multipeptide dysfunction leads to expression of a range of non-motor symptoms now known to be integral to the concept of PD and preceding the diagnosis of motor PD. Some non-motor symptoms in PD may have a dopaminergic basis and in this review, we investigate the evidence for this based on imaging techniques using dopamine-based radioligands. To discuss non-motor symptoms we follow the classification as outlined by the validated PD non-motor symptoms scale.
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spelling pubmed-54455922017-06-23 Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis? Qamar, MA Sauerbier, A Politis, M Carr, H Loehrer, P A Chaudhuri, K Ray NPJ Parkinsons Dis Review Article Parkinson’s disease (PD) is now considered to be a multisystemic disorder consequent on multineuropeptide dysfunction including dopaminergic, serotonergic, cholinergic, and noradrenergic systems. This multipeptide dysfunction leads to expression of a range of non-motor symptoms now known to be integral to the concept of PD and preceding the diagnosis of motor PD. Some non-motor symptoms in PD may have a dopaminergic basis and in this review, we investigate the evidence for this based on imaging techniques using dopamine-based radioligands. To discuss non-motor symptoms we follow the classification as outlined by the validated PD non-motor symptoms scale. Nature Publishing Group UK 2017-01-25 /pmc/articles/PMC5445592/ /pubmed/28649605 http://dx.doi.org/10.1038/s41531-016-0006-9 Text en © The Author(s) 2017, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review Article
Qamar, MA
Sauerbier, A
Politis, M
Carr, H
Loehrer, P A
Chaudhuri, K Ray
Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?
title Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?
title_full Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?
title_fullStr Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?
title_full_unstemmed Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?
title_short Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?
title_sort presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of parkinson’s disease: evidence for dopaminergic basis?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445592/
https://www.ncbi.nlm.nih.gov/pubmed/28649605
http://dx.doi.org/10.1038/s41531-016-0006-9
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