A functionally significant SNP in TP53 and breast cancer risk in African-American women

A coding region polymorphism exists in the TP53 gene (Pro47Ser; rs1800371) in individuals of African descent, which reduces p53 tumor suppressor function in a mouse model. It has been unclear whether this functionally significant polymorphism alters cancer risk in humans. This analysis included 6907...

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Detalles Bibliográficos
Autores principales: Murphy, Maureen E., Liu, Song, Yao, Song, Huo, Dezheng, Liu, Qin, Dolfi, Sonia C., Hirshfield, Kim M., Hong, Chi-Chen, Hu, Qiang, Olshan, Andrew F., Ogundiran, Temidayo O., Adebamowo, Clement, Domchek, Susan M., Nathanson, Katherine L., Nemesure, Barbara, Ambs, Stefan, Blot, William J., Feng, Ye, John, Esther M., Bernstein, Leslie, Zheng, Wei, Hu, Jennifer J., Ziegler, Regina G., Nyante, Sarah, Ingles, Sue A., Press, Michael F., Deming, Sandra L., Rodriguez-Gil, Jorge L., Haiman, Christopher A., Olopade, Olufunmilayo I., Lunetta, Kathryn L., Palmer, Julie R., Ambrosone, Christine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445618/
https://www.ncbi.nlm.nih.gov/pubmed/28649645
http://dx.doi.org/10.1038/s41523-017-0007-9

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