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Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
BACKGROUND: Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH(CSF )was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH(CSF )was first correlated with demograph...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544567/ https://www.ncbi.nlm.nih.gov/pubmed/15606911 http://dx.doi.org/10.1186/1471-2202-5-58 |
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author | Baraniuk, James N Maibach, Hilda Whalen, Gail Clauw, Daniel J |
author_facet | Baraniuk, James N Maibach, Hilda Whalen, Gail Clauw, Daniel J |
author_sort | Baraniuk, James N |
collection | PubMed |
description | BACKGROUND: Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH(CSF )was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH(CSF )was first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses to pain, exercise and other stressors. Significant factors were used for linear regression modeling. RESULTS: Highly significant correlations were found despite the small number of subjects. Three models were defined: (a) CRH(CSF )with blood glucose and sodium (explained variance = 0.979, adjusted R(2 )= 0.958, p = 0.02 by 2-tailed testing); (b) CRH(CSF )with resting respiratory and heart rates (R(2 )= 0.963, adjusted R(2 )= 0.939, p = 0.007); and (c) CRH(CSF )with SF-36 Vitality and Multidimensional Fatigue Inventory Physical Fatigue domains (R(2 )= 0.859, adjusted R(2 )= 0.789, p = 0.02). CONCLUSIONS: Low CRH(CSF )was predicted by lower glucose, respiratory and heart rates, and higher sodium and psychometric constructs of well being. Responses at peak exercise and to other acute stressors were not correlated. CRH(CSF )may have reflected an overall, or chronic, set-point for physiological responses, but did not predict the reserves available to respond to immediate stressors. |
format | Text |
id | pubmed-544567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-5445672005-01-16 Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans Baraniuk, James N Maibach, Hilda Whalen, Gail Clauw, Daniel J BMC Neurosci Research Article BACKGROUND: Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH(CSF )was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH(CSF )was first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses to pain, exercise and other stressors. Significant factors were used for linear regression modeling. RESULTS: Highly significant correlations were found despite the small number of subjects. Three models were defined: (a) CRH(CSF )with blood glucose and sodium (explained variance = 0.979, adjusted R(2 )= 0.958, p = 0.02 by 2-tailed testing); (b) CRH(CSF )with resting respiratory and heart rates (R(2 )= 0.963, adjusted R(2 )= 0.939, p = 0.007); and (c) CRH(CSF )with SF-36 Vitality and Multidimensional Fatigue Inventory Physical Fatigue domains (R(2 )= 0.859, adjusted R(2 )= 0.789, p = 0.02). CONCLUSIONS: Low CRH(CSF )was predicted by lower glucose, respiratory and heart rates, and higher sodium and psychometric constructs of well being. Responses at peak exercise and to other acute stressors were not correlated. CRH(CSF )may have reflected an overall, or chronic, set-point for physiological responses, but did not predict the reserves available to respond to immediate stressors. BioMed Central 2004-12-17 /pmc/articles/PMC544567/ /pubmed/15606911 http://dx.doi.org/10.1186/1471-2202-5-58 Text en Copyright © 2004 Baraniuk et al; licensee BioMed Central Ltd. |
spellingShingle | Research Article Baraniuk, James N Maibach, Hilda Whalen, Gail Clauw, Daniel J Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
title | Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
title_full | Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
title_fullStr | Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
title_full_unstemmed | Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
title_short | Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
title_sort | covariates of corticotropin-releasing hormone (crh) concentrations in cerebrospinal fluid (csf) from healthy humans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544567/ https://www.ncbi.nlm.nih.gov/pubmed/15606911 http://dx.doi.org/10.1186/1471-2202-5-58 |
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