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Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans

BACKGROUND: Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH(CSF )was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH(CSF )was first correlated with demograph...

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Detalles Bibliográficos
Autores principales: Baraniuk, James N, Maibach, Hilda, Whalen, Gail, Clauw, Daniel J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544567/
https://www.ncbi.nlm.nih.gov/pubmed/15606911
http://dx.doi.org/10.1186/1471-2202-5-58
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author Baraniuk, James N
Maibach, Hilda
Whalen, Gail
Clauw, Daniel J
author_facet Baraniuk, James N
Maibach, Hilda
Whalen, Gail
Clauw, Daniel J
author_sort Baraniuk, James N
collection PubMed
description BACKGROUND: Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH(CSF )was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH(CSF )was first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses to pain, exercise and other stressors. Significant factors were used for linear regression modeling. RESULTS: Highly significant correlations were found despite the small number of subjects. Three models were defined: (a) CRH(CSF )with blood glucose and sodium (explained variance = 0.979, adjusted R(2 )= 0.958, p = 0.02 by 2-tailed testing); (b) CRH(CSF )with resting respiratory and heart rates (R(2 )= 0.963, adjusted R(2 )= 0.939, p = 0.007); and (c) CRH(CSF )with SF-36 Vitality and Multidimensional Fatigue Inventory Physical Fatigue domains (R(2 )= 0.859, adjusted R(2 )= 0.789, p = 0.02). CONCLUSIONS: Low CRH(CSF )was predicted by lower glucose, respiratory and heart rates, and higher sodium and psychometric constructs of well being. Responses at peak exercise and to other acute stressors were not correlated. CRH(CSF )may have reflected an overall, or chronic, set-point for physiological responses, but did not predict the reserves available to respond to immediate stressors.
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spelling pubmed-5445672005-01-16 Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans Baraniuk, James N Maibach, Hilda Whalen, Gail Clauw, Daniel J BMC Neurosci Research Article BACKGROUND: Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH(CSF )was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH(CSF )was first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses to pain, exercise and other stressors. Significant factors were used for linear regression modeling. RESULTS: Highly significant correlations were found despite the small number of subjects. Three models were defined: (a) CRH(CSF )with blood glucose and sodium (explained variance = 0.979, adjusted R(2 )= 0.958, p = 0.02 by 2-tailed testing); (b) CRH(CSF )with resting respiratory and heart rates (R(2 )= 0.963, adjusted R(2 )= 0.939, p = 0.007); and (c) CRH(CSF )with SF-36 Vitality and Multidimensional Fatigue Inventory Physical Fatigue domains (R(2 )= 0.859, adjusted R(2 )= 0.789, p = 0.02). CONCLUSIONS: Low CRH(CSF )was predicted by lower glucose, respiratory and heart rates, and higher sodium and psychometric constructs of well being. Responses at peak exercise and to other acute stressors were not correlated. CRH(CSF )may have reflected an overall, or chronic, set-point for physiological responses, but did not predict the reserves available to respond to immediate stressors. BioMed Central 2004-12-17 /pmc/articles/PMC544567/ /pubmed/15606911 http://dx.doi.org/10.1186/1471-2202-5-58 Text en Copyright © 2004 Baraniuk et al; licensee BioMed Central Ltd.
spellingShingle Research Article
Baraniuk, James N
Maibach, Hilda
Whalen, Gail
Clauw, Daniel J
Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
title Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
title_full Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
title_fullStr Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
title_full_unstemmed Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
title_short Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans
title_sort covariates of corticotropin-releasing hormone (crh) concentrations in cerebrospinal fluid (csf) from healthy humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544567/
https://www.ncbi.nlm.nih.gov/pubmed/15606911
http://dx.doi.org/10.1186/1471-2202-5-58
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