Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium

Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal ra...

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Detalles Bibliográficos
Autores principales: Minuth, Will W., Denk, Lucia, Glashauser, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445860/
http://dx.doi.org/10.3390/ma3042369
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author Minuth, Will W.
Denk, Lucia
Glashauser, Anne
author_facet Minuth, Will W.
Denk, Lucia
Glashauser, Anne
author_sort Minuth, Will W.
collection PubMed
description Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal rabbit kidney and mounted between layers of polyester fleece. It creates an artificial interstitium and replaces coating by extracellular matrix proteins. Tubulogenic development is induced by aldosterone. Electron microscopy illuminates growth of tubules in close vicinity to polyester fibers. Tubules contain a differentiated epithelium. The spatial extension of tubules opens a new strategy for testing morphogenic drugs and biocompatible fleece materials.
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spelling pubmed-54458602017-07-28 Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium Minuth, Will W. Denk, Lucia Glashauser, Anne Materials (Basel) Review Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal rabbit kidney and mounted between layers of polyester fleece. It creates an artificial interstitium and replaces coating by extracellular matrix proteins. Tubulogenic development is induced by aldosterone. Electron microscopy illuminates growth of tubules in close vicinity to polyester fibers. Tubules contain a differentiated epithelium. The spatial extension of tubules opens a new strategy for testing morphogenic drugs and biocompatible fleece materials. Molecular Diversity Preservation International 2010-03-26 /pmc/articles/PMC5445860/ http://dx.doi.org/10.3390/ma3042369 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Minuth, Will W.
Denk, Lucia
Glashauser, Anne
Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
title Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
title_full Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
title_fullStr Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
title_full_unstemmed Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
title_short Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
title_sort towards a guided regeneration of renal tubules at a polyester interstitium
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445860/
http://dx.doi.org/10.3390/ma3042369
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