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Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

OBJECTIVES: Tristetraprolin (TTP), a negative regulator of many pro-inflammatory genes, is strongly expressed in rheumatoid synovial cells. The mitogen-activated protein kinase (MAPK) p38 pathway mediates the inactivation of TTP via phosphorylation of two serine residues. We wished to test the hypot...

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Detalles Bibliográficos
Autores principales:	Ross, E A, Naylor, A J, O'Neil, J D, Crowley, T, Ridley, M L, Crowe, J, Smallie, T, Tang, T J, Turner, J D, Norling, L V, Dominguez, S, Perlman, H, Verrills, N M, Kollias, G, Vitek, M P, Filer, A, Buckley, C D, Dean, J L, Clark, A R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446007/ https://www.ncbi.nlm.nih.gov/pubmed/27597652 http://dx.doi.org/10.1136/annrheumdis-2016-209424

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