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Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the [Formula: see text] statistic

Background: MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and prov...

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Detalles Bibliográficos
Autores principales:	Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala A, Thompson, John R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Mendelian Randomisation and Instrumental Variable Analysis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446088/ https://www.ncbi.nlm.nih.gov/pubmed/27616674 http://dx.doi.org/10.1093/ije/dyw220

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