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Tau secretion is correlated to an increase of Golgi dynamics

Tau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer’disease (AD). Neuronal hyperexcitability was shown to significantly increase Tau release by neurons. We confirmed this in the present study. In a previous study, it was demonstrated that hyperexc...

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Detalles Bibliográficos
Autores principales: Mohamed, Nguyen-Vi, Desjardins, Alexandre, Leclerc, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446162/
https://www.ncbi.nlm.nih.gov/pubmed/28552936
http://dx.doi.org/10.1371/journal.pone.0178288
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author Mohamed, Nguyen-Vi
Desjardins, Alexandre
Leclerc, Nicole
author_facet Mohamed, Nguyen-Vi
Desjardins, Alexandre
Leclerc, Nicole
author_sort Mohamed, Nguyen-Vi
collection PubMed
description Tau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer’disease (AD). Neuronal hyperexcitability was shown to significantly increase Tau release by neurons. We confirmed this in the present study. In a previous study, it was demonstrated that hyperexcitability induces Golgi apparatus dynamics resulting in its fragmentation. Our present results revealed that the increase of Tau secretion upon hyperexcitability could be significantly reduced by preventing Golgi dynamics through the inactivation of cdk5. We then verified whether a Golgi fragmentation not induced by hyperexcitability could also increase Tau secretion. The suppression of Rab1A, Rab GTPase associated with the Golgi membranes, known to induce a Golgi fragmentation increased Tau secretion by both neurons and HeLa cells. Although it remains to be demonstrated whether the Golgi is directly involved in Tau secretion, the present results demonstrate that its dynamics are correlated to a modulation of Tau secretion.
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spelling pubmed-54461622017-06-12 Tau secretion is correlated to an increase of Golgi dynamics Mohamed, Nguyen-Vi Desjardins, Alexandre Leclerc, Nicole PLoS One Research Article Tau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer’disease (AD). Neuronal hyperexcitability was shown to significantly increase Tau release by neurons. We confirmed this in the present study. In a previous study, it was demonstrated that hyperexcitability induces Golgi apparatus dynamics resulting in its fragmentation. Our present results revealed that the increase of Tau secretion upon hyperexcitability could be significantly reduced by preventing Golgi dynamics through the inactivation of cdk5. We then verified whether a Golgi fragmentation not induced by hyperexcitability could also increase Tau secretion. The suppression of Rab1A, Rab GTPase associated with the Golgi membranes, known to induce a Golgi fragmentation increased Tau secretion by both neurons and HeLa cells. Although it remains to be demonstrated whether the Golgi is directly involved in Tau secretion, the present results demonstrate that its dynamics are correlated to a modulation of Tau secretion. Public Library of Science 2017-05-26 /pmc/articles/PMC5446162/ /pubmed/28552936 http://dx.doi.org/10.1371/journal.pone.0178288 Text en © 2017 Mohamed et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mohamed, Nguyen-Vi
Desjardins, Alexandre
Leclerc, Nicole
Tau secretion is correlated to an increase of Golgi dynamics
title Tau secretion is correlated to an increase of Golgi dynamics
title_full Tau secretion is correlated to an increase of Golgi dynamics
title_fullStr Tau secretion is correlated to an increase of Golgi dynamics
title_full_unstemmed Tau secretion is correlated to an increase of Golgi dynamics
title_short Tau secretion is correlated to an increase of Golgi dynamics
title_sort tau secretion is correlated to an increase of golgi dynamics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446162/
https://www.ncbi.nlm.nih.gov/pubmed/28552936
http://dx.doi.org/10.1371/journal.pone.0178288
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