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Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene

BACKGROUND AND AIMS: Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein cholesterol-receptors (LDL-R) and thereby regulate l...

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Detalles Bibliográficos
Autores principales:	Fairoozy, Roaa Hani, Cooper, Jackie, White, Jon, Giambartolomei, Claudia, Folkersen, Lasse, Wannamethee, S. Goya, Jefferis, Barbara J., Whincup, Peter, Ben-Shlomo, Yoav, Kumari, Meena, Kivimaki, Mika, Wong, Andrew, Hardy, Rebecca, Kuh, Diana, Gaunt, Tom R., Casas, J.P., McLachlan, Stela, Price, Jackie F., Hingorani, Aroon, Franco-Cereceda, Anders, Grewal, Thomas, Kalea, Anastasia Z., Humphries, Steve E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446264/ https://www.ncbi.nlm.nih.gov/pubmed/28456096 http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.010

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