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Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants

OBJECTIVE: Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g). STUDY DESIGN: We identified all extremely low birth weight infants admitted to one of 323 neonatal intensive care units from 2007 to 201...

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Autores principales: Downey, L. Corbin, Cotten, C. Michael, Hornik, Christoph P., Laughon, Matthew M., Tolia, Veeral N., Clark, Reese H., Smith, P. Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446291/
https://www.ncbi.nlm.nih.gov/pubmed/28125094
http://dx.doi.org/10.1038/jp.2016.274
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author Downey, L. Corbin
Cotten, C. Michael
Hornik, Christoph P.
Laughon, Matthew M.
Tolia, Veeral N.
Clark, Reese H.
Smith, P. Brian
author_facet Downey, L. Corbin
Cotten, C. Michael
Hornik, Christoph P.
Laughon, Matthew M.
Tolia, Veeral N.
Clark, Reese H.
Smith, P. Brian
author_sort Downey, L. Corbin
collection PubMed
description OBJECTIVE: Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g). STUDY DESIGN: We identified all extremely low birth weight infants admitted to one of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero. RESULTS: Of the 28,035 infants, 11,789 (42%) were exposed to antenatal magnesium. There was no difference in the risk of spontaneous intestinal perforation, odds ratio=1.08 (95% confidence interval; 0.91–1.29), between infants exposed and unexposed to antenatal magnesium. Mortality in the first 21 days after birth was lower in the magnesium exposed infants, odds ratio=0.76 (0.70–0.83). CONCLUSION: Antenatal magnesium exposure in extremely low birth weight infants was not associated with increased risk of spontaneous intestinal perforation.
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spelling pubmed-54462912017-07-26 Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants Downey, L. Corbin Cotten, C. Michael Hornik, Christoph P. Laughon, Matthew M. Tolia, Veeral N. Clark, Reese H. Smith, P. Brian J Perinatol Article OBJECTIVE: Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g). STUDY DESIGN: We identified all extremely low birth weight infants admitted to one of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero. RESULTS: Of the 28,035 infants, 11,789 (42%) were exposed to antenatal magnesium. There was no difference in the risk of spontaneous intestinal perforation, odds ratio=1.08 (95% confidence interval; 0.91–1.29), between infants exposed and unexposed to antenatal magnesium. Mortality in the first 21 days after birth was lower in the magnesium exposed infants, odds ratio=0.76 (0.70–0.83). CONCLUSION: Antenatal magnesium exposure in extremely low birth weight infants was not associated with increased risk of spontaneous intestinal perforation. 2017-01-26 2017-06 /pmc/articles/PMC5446291/ /pubmed/28125094 http://dx.doi.org/10.1038/jp.2016.274 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Downey, L. Corbin
Cotten, C. Michael
Hornik, Christoph P.
Laughon, Matthew M.
Tolia, Veeral N.
Clark, Reese H.
Smith, P. Brian
Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
title Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
title_full Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
title_fullStr Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
title_full_unstemmed Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
title_short Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
title_sort association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446291/
https://www.ncbi.nlm.nih.gov/pubmed/28125094
http://dx.doi.org/10.1038/jp.2016.274
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