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Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants
OBJECTIVE: Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g). STUDY DESIGN: We identified all extremely low birth weight infants admitted to one of 323 neonatal intensive care units from 2007 to 201...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446291/ https://www.ncbi.nlm.nih.gov/pubmed/28125094 http://dx.doi.org/10.1038/jp.2016.274 |
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author | Downey, L. Corbin Cotten, C. Michael Hornik, Christoph P. Laughon, Matthew M. Tolia, Veeral N. Clark, Reese H. Smith, P. Brian |
author_facet | Downey, L. Corbin Cotten, C. Michael Hornik, Christoph P. Laughon, Matthew M. Tolia, Veeral N. Clark, Reese H. Smith, P. Brian |
author_sort | Downey, L. Corbin |
collection | PubMed |
description | OBJECTIVE: Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g). STUDY DESIGN: We identified all extremely low birth weight infants admitted to one of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero. RESULTS: Of the 28,035 infants, 11,789 (42%) were exposed to antenatal magnesium. There was no difference in the risk of spontaneous intestinal perforation, odds ratio=1.08 (95% confidence interval; 0.91–1.29), between infants exposed and unexposed to antenatal magnesium. Mortality in the first 21 days after birth was lower in the magnesium exposed infants, odds ratio=0.76 (0.70–0.83). CONCLUSION: Antenatal magnesium exposure in extremely low birth weight infants was not associated with increased risk of spontaneous intestinal perforation. |
format | Online Article Text |
id | pubmed-5446291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-54462912017-07-26 Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants Downey, L. Corbin Cotten, C. Michael Hornik, Christoph P. Laughon, Matthew M. Tolia, Veeral N. Clark, Reese H. Smith, P. Brian J Perinatol Article OBJECTIVE: Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g). STUDY DESIGN: We identified all extremely low birth weight infants admitted to one of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero. RESULTS: Of the 28,035 infants, 11,789 (42%) were exposed to antenatal magnesium. There was no difference in the risk of spontaneous intestinal perforation, odds ratio=1.08 (95% confidence interval; 0.91–1.29), between infants exposed and unexposed to antenatal magnesium. Mortality in the first 21 days after birth was lower in the magnesium exposed infants, odds ratio=0.76 (0.70–0.83). CONCLUSION: Antenatal magnesium exposure in extremely low birth weight infants was not associated with increased risk of spontaneous intestinal perforation. 2017-01-26 2017-06 /pmc/articles/PMC5446291/ /pubmed/28125094 http://dx.doi.org/10.1038/jp.2016.274 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Downey, L. Corbin Cotten, C. Michael Hornik, Christoph P. Laughon, Matthew M. Tolia, Veeral N. Clark, Reese H. Smith, P. Brian Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
title | Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
title_full | Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
title_fullStr | Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
title_full_unstemmed | Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
title_short | Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
title_sort | association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446291/ https://www.ncbi.nlm.nih.gov/pubmed/28125094 http://dx.doi.org/10.1038/jp.2016.274 |
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