Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function

The level of the transcription factor Nanog directly determines the efficiency of mouse embryonic stem cell self-renewal. Nanog protein exists as a dimer with the dimerization domain composed of a simple repeat region in which every fifth residue is a tryptophan, the tryptophan repeat (WR). Although...

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Detalles Bibliográficos
Autores principales: Mullin, Nicholas P., Gagliardi, Alessia, Khoa, Le Tran Phuc, Colby, Douglas, Hall-Ponsele, Elisa, Rowe, Arthur J., Chambers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446312/
https://www.ncbi.nlm.nih.gov/pubmed/27939294
http://dx.doi.org/10.1016/j.jmb.2016.12.001

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