The STR/ort mouse model of spontaneous osteoarthritis – an update

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. M...

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Detalles Bibliográficos
Autores principales: Staines, K.A., Poulet, B., Wentworth, D.N., Pitsillides, A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446355/
https://www.ncbi.nlm.nih.gov/pubmed/27965138
http://dx.doi.org/10.1016/j.joca.2016.12.014
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author Staines, K.A.
Poulet, B.
Wentworth, D.N.
Pitsillides, A.A.
author_facet Staines, K.A.
Poulet, B.
Wentworth, D.N.
Pitsillides, A.A.
author_sort Staines, K.A.
collection PubMed
description Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.
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spelling pubmed-54463552017-06-01 The STR/ort mouse model of spontaneous osteoarthritis – an update Staines, K.A. Poulet, B. Wentworth, D.N. Pitsillides, A.A. Osteoarthritis Cartilage Review Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes. W.B. Saunders For The Osteoarthritis Research Society 2017-06 /pmc/articles/PMC5446355/ /pubmed/27965138 http://dx.doi.org/10.1016/j.joca.2016.12.014 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Staines, K.A.
Poulet, B.
Wentworth, D.N.
Pitsillides, A.A.
The STR/ort mouse model of spontaneous osteoarthritis – an update
title The STR/ort mouse model of spontaneous osteoarthritis – an update
title_full The STR/ort mouse model of spontaneous osteoarthritis – an update
title_fullStr The STR/ort mouse model of spontaneous osteoarthritis – an update
title_full_unstemmed The STR/ort mouse model of spontaneous osteoarthritis – an update
title_short The STR/ort mouse model of spontaneous osteoarthritis – an update
title_sort str/ort mouse model of spontaneous osteoarthritis – an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446355/
https://www.ncbi.nlm.nih.gov/pubmed/27965138
http://dx.doi.org/10.1016/j.joca.2016.12.014
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