Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry

Prolyl oligopeptidase (PREP) is conserved in many organisms across life. It is involved in numerous processes including brain function and neuropathology, that require more than its strict proteolytic role. It consists of a seven-bladed β-propeller juxtaposed to a catalytic α/β-hydrolase domain. The...

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Detalles Bibliográficos
Autores principales: Tsirigotaki, Alexandra, Elzen, Roos Van, Veken, Pieter Van Der, Lambeir, Anne-Marie, Economou, Anastassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446394/
https://www.ncbi.nlm.nih.gov/pubmed/28550305
http://dx.doi.org/10.1038/s41598-017-02550-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446394/
https://www.ncbi.nlm.nih.gov/pubmed/28550305
http://dx.doi.org/10.1038/s41598-017-02550-1

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