Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that promote and sustain autophagy are less well defined. Here we report that the epig...

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Detalles Bibliográficos
Autores principales: Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin, Long, Jaclyn S., New, Maria, Van Acker, Tim, Tooze, Sharon A., Lowe, Scott W., Dikic, Ivan, Ryan, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
https://www.ncbi.nlm.nih.gov/pubmed/28525743
http://dx.doi.org/10.1016/j.molcel.2017.04.027

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