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Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum
Human adenoviral serotype 5 (HAdV-5) vectors have predominantly hepatic tropism when delivered intravascularly, resulting in immune activation and toxicity. Coagulation factor X (FX) binding to HAdV-5 mediates liver transduction and provides protection from virion neutralization in mice. FX is dispe...
Autores principales: | Lopez-Gordo, Estrella, Doszpoly, Andor, Duffy, Margaret R., Coughlan, Lynda, Bradshaw, Angela C., White, Katie M., Denby, Laura, Nicklin, Stuart A., Baker, Andrew H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446653/ https://www.ncbi.nlm.nih.gov/pubmed/28381574 http://dx.doi.org/10.1128/JVI.02487-16 |
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