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Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning
PURPOSE: To analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT). METHODS: Retrospective analysis of enhanced depth SD-OCT images of Non-pathological myopic eyes in comparison with age-matched healthy controls was p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446694/ https://www.ncbi.nlm.nih.gov/pubmed/28560051 http://dx.doi.org/10.1186/s40942-017-0081-z |
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author | Alshareef, Rayan A. Khuthaila, Mohammed K. Januwada, Manideepak Goud, Abhilash Ferrara, Daniela Chhablani, Jay |
author_facet | Alshareef, Rayan A. Khuthaila, Mohammed K. Januwada, Manideepak Goud, Abhilash Ferrara, Daniela Chhablani, Jay |
author_sort | Alshareef, Rayan A. |
collection | PubMed |
description | PURPOSE: To analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT). METHODS: Retrospective analysis of enhanced depth SD-OCT images of Non-pathological myopic eyes in comparison with age-matched healthy controls was performed. Choroidal thickness (CT) and large choroidal vessel thickness (LCVT) were measured at the fovea, 750 µm nasally from fovea (N(750)) and 750 µm temporally (T(750)) from fovea. Medium choroidal vessel thickness (MCVT) was calculated by subtracting LCVT from CT. Choriocapillaris was encompassed by MCVT, given its reduced thickness. Linear regression analysis evaluated the relationship between age and axial with CT, LCVT and MCVT. RESULTS: The study group comprised 42 eyes of 31 patients (mean age 46.13 ± 15.63; 15 females). Control group included 57 eyes of 34 patients (mean age of 42.3 ± 15.29; 24 females). Mean axial length in myopic eyes and control group was 26.57 ± 1.27 and 23.59 ± 0.99 mm respectively. Myopic eyes showed significant thinning of MCVT and CT at all locations (p < 0.0001) compared to controls, unlike LCVT (p > 0.05). With each decade, thinning of up to 37 µm in CT was noted along with thinning of LCVT (up to 22.6 µm) and MCVT (up to 25 µm). Each mm increase in axial length caused 38.2 µm thinning of choroid along with LCVT (<10 µm), however, MCVT showed more notable thinning (>30 µm). CONCLUSION: Significant thinning of MCVT was noted in non-pathological myopic eyes in comparison to healthy subjects. It appears that MCVT has stronger relationship with age and axial length. |
format | Online Article Text |
id | pubmed-5446694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54466942017-05-30 Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning Alshareef, Rayan A. Khuthaila, Mohammed K. Januwada, Manideepak Goud, Abhilash Ferrara, Daniela Chhablani, Jay Int J Retina Vitreous Original Article PURPOSE: To analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT). METHODS: Retrospective analysis of enhanced depth SD-OCT images of Non-pathological myopic eyes in comparison with age-matched healthy controls was performed. Choroidal thickness (CT) and large choroidal vessel thickness (LCVT) were measured at the fovea, 750 µm nasally from fovea (N(750)) and 750 µm temporally (T(750)) from fovea. Medium choroidal vessel thickness (MCVT) was calculated by subtracting LCVT from CT. Choriocapillaris was encompassed by MCVT, given its reduced thickness. Linear regression analysis evaluated the relationship between age and axial with CT, LCVT and MCVT. RESULTS: The study group comprised 42 eyes of 31 patients (mean age 46.13 ± 15.63; 15 females). Control group included 57 eyes of 34 patients (mean age of 42.3 ± 15.29; 24 females). Mean axial length in myopic eyes and control group was 26.57 ± 1.27 and 23.59 ± 0.99 mm respectively. Myopic eyes showed significant thinning of MCVT and CT at all locations (p < 0.0001) compared to controls, unlike LCVT (p > 0.05). With each decade, thinning of up to 37 µm in CT was noted along with thinning of LCVT (up to 22.6 µm) and MCVT (up to 25 µm). Each mm increase in axial length caused 38.2 µm thinning of choroid along with LCVT (<10 µm), however, MCVT showed more notable thinning (>30 µm). CONCLUSION: Significant thinning of MCVT was noted in non-pathological myopic eyes in comparison to healthy subjects. It appears that MCVT has stronger relationship with age and axial length. BioMed Central 2017-05-26 /pmc/articles/PMC5446694/ /pubmed/28560051 http://dx.doi.org/10.1186/s40942-017-0081-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Article Alshareef, Rayan A. Khuthaila, Mohammed K. Januwada, Manideepak Goud, Abhilash Ferrara, Daniela Chhablani, Jay Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
title | Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
title_full | Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
title_fullStr | Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
title_full_unstemmed | Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
title_short | Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
title_sort | choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446694/ https://www.ncbi.nlm.nih.gov/pubmed/28560051 http://dx.doi.org/10.1186/s40942-017-0081-z |
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