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Kimura’s disease affecting the axillary lymph nodes: a case report

BACKGROUND: Kimura’s disease (KD; eosinophilic granuloma of soft tissue) is an inflammatory granulomatous disorder of unknown cause with eosinophilic infiltration that occurs mainly in soft tissue. KD occurs mainly in the head and neck, but development in the axillary region is very rare. CASE PRESE...

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Autores principales: Kuroda, Kenji, Kashiwagi, Shinichiro, Teraoka, Hitoshi, Kinoshita, Haruhito, Nanbara, Mikio, Noda, Eiji, Chikugo, Takaaki, Hirakawa, Kosei, Ohira, Masaichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446720/
https://www.ncbi.nlm.nih.gov/pubmed/28549475
http://dx.doi.org/10.1186/s12893-017-0260-8
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author Kuroda, Kenji
Kashiwagi, Shinichiro
Teraoka, Hitoshi
Kinoshita, Haruhito
Nanbara, Mikio
Noda, Eiji
Chikugo, Takaaki
Hirakawa, Kosei
Ohira, Masaichi
author_facet Kuroda, Kenji
Kashiwagi, Shinichiro
Teraoka, Hitoshi
Kinoshita, Haruhito
Nanbara, Mikio
Noda, Eiji
Chikugo, Takaaki
Hirakawa, Kosei
Ohira, Masaichi
author_sort Kuroda, Kenji
collection PubMed
description BACKGROUND: Kimura’s disease (KD; eosinophilic granuloma of soft tissue) is an inflammatory granulomatous disorder of unknown cause with eosinophilic infiltration that occurs mainly in soft tissue. KD occurs mainly in the head and neck, but development in the axillary region is very rare. CASE PRESENTATION: A 74-year-old Japanese woman was evaluated for a mass that she noted in the left axillary region. On physical examination, there was a palpable, thumb-sized, hard, elastic, freely movable mass in the left axilla. Blood tests showed elevated soluble interleukin-2 receptor (sIL-2R), normal serum immunoglobulin (Ig) G4, and elevated serum IgE. Ultrasonography of the left axilla showed multiple lymph nodes (LNs) with irregular margins in which central hyperechogenicity was lost. A systemic search by computed tomography (CT) showed no systemic lymphadenopathy or other mass-like lesions suspicious for a primary tumour other than in the left axillary LNs. Biopsy of an excised LN was performed under local anaesthesia for a definitive diagnosis. Histopathology showed various-sized lymphoid follicles, large nodular lesions with an enlarged mantle zone, multiple various-sized germinal centres in single nodules, and eosinophilic infiltration between the nodes. Immunohistochemical (IHC) staining of the germinal centres was positive for cluster of differentiation (CD) 10, positive for B-cell lymphoma (bcl)-6, and negative for bcl-2. These findings led to a diagnosis of KD. Ultrasound after 3 months of follow-up showed disappearance of the axillary lymphadenopathy. CONCLUSIONS: A very rare case of KD in the axillary LNs was described. KD has the potential to occur in any region.
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spelling pubmed-54467202017-05-30 Kimura’s disease affecting the axillary lymph nodes: a case report Kuroda, Kenji Kashiwagi, Shinichiro Teraoka, Hitoshi Kinoshita, Haruhito Nanbara, Mikio Noda, Eiji Chikugo, Takaaki Hirakawa, Kosei Ohira, Masaichi BMC Surg Case Report BACKGROUND: Kimura’s disease (KD; eosinophilic granuloma of soft tissue) is an inflammatory granulomatous disorder of unknown cause with eosinophilic infiltration that occurs mainly in soft tissue. KD occurs mainly in the head and neck, but development in the axillary region is very rare. CASE PRESENTATION: A 74-year-old Japanese woman was evaluated for a mass that she noted in the left axillary region. On physical examination, there was a palpable, thumb-sized, hard, elastic, freely movable mass in the left axilla. Blood tests showed elevated soluble interleukin-2 receptor (sIL-2R), normal serum immunoglobulin (Ig) G4, and elevated serum IgE. Ultrasonography of the left axilla showed multiple lymph nodes (LNs) with irregular margins in which central hyperechogenicity was lost. A systemic search by computed tomography (CT) showed no systemic lymphadenopathy or other mass-like lesions suspicious for a primary tumour other than in the left axillary LNs. Biopsy of an excised LN was performed under local anaesthesia for a definitive diagnosis. Histopathology showed various-sized lymphoid follicles, large nodular lesions with an enlarged mantle zone, multiple various-sized germinal centres in single nodules, and eosinophilic infiltration between the nodes. Immunohistochemical (IHC) staining of the germinal centres was positive for cluster of differentiation (CD) 10, positive for B-cell lymphoma (bcl)-6, and negative for bcl-2. These findings led to a diagnosis of KD. Ultrasound after 3 months of follow-up showed disappearance of the axillary lymphadenopathy. CONCLUSIONS: A very rare case of KD in the axillary LNs was described. KD has the potential to occur in any region. BioMed Central 2017-05-26 /pmc/articles/PMC5446720/ /pubmed/28549475 http://dx.doi.org/10.1186/s12893-017-0260-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kuroda, Kenji
Kashiwagi, Shinichiro
Teraoka, Hitoshi
Kinoshita, Haruhito
Nanbara, Mikio
Noda, Eiji
Chikugo, Takaaki
Hirakawa, Kosei
Ohira, Masaichi
Kimura’s disease affecting the axillary lymph nodes: a case report
title Kimura’s disease affecting the axillary lymph nodes: a case report
title_full Kimura’s disease affecting the axillary lymph nodes: a case report
title_fullStr Kimura’s disease affecting the axillary lymph nodes: a case report
title_full_unstemmed Kimura’s disease affecting the axillary lymph nodes: a case report
title_short Kimura’s disease affecting the axillary lymph nodes: a case report
title_sort kimura’s disease affecting the axillary lymph nodes: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446720/
https://www.ncbi.nlm.nih.gov/pubmed/28549475
http://dx.doi.org/10.1186/s12893-017-0260-8
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