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Abnormal wiring of CCK+ basket cells disrupts spatial information coding

The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide ch...

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Detalles Bibliográficos
Autores principales: del Pino, Isabel, Brotons-Mas, Jorge R., Marques-Smith, André, Marighetto, Aline, Frick, Andreas, Marín, Oscar, Rico, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446788/
https://www.ncbi.nlm.nih.gov/pubmed/28394324
http://dx.doi.org/10.1038/nn.4544
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author del Pino, Isabel
Brotons-Mas, Jorge R.
Marques-Smith, André
Marighetto, Aline
Frick, Andreas
Marín, Oscar
Rico, Beatriz
author_facet del Pino, Isabel
Brotons-Mas, Jorge R.
Marques-Smith, André
Marighetto, Aline
Frick, Andreas
Marín, Oscar
Rico, Beatriz
author_sort del Pino, Isabel
collection PubMed
description The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 is required for the normal integration of CCK+/VGlut3+ basket cells into cortical circuits. The number of inhibitory synapses made by CCK+/VGlut3+ basket cells and the inhibitory drive they exert on pyramidal cells are severely reduced in conditional mice lacking ErbB4. Developmental disruption of the connectivity of these cells diminishes the power of theta oscillations during exploratory behavior, disrupts spatial coding by place cells, and causes selective alterations in spatial learning and memory in adult mice. These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding information in hippocampus.
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spelling pubmed-54467882017-10-10 Abnormal wiring of CCK+ basket cells disrupts spatial information coding del Pino, Isabel Brotons-Mas, Jorge R. Marques-Smith, André Marighetto, Aline Frick, Andreas Marín, Oscar Rico, Beatriz Nat Neurosci Article The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 is required for the normal integration of CCK+/VGlut3+ basket cells into cortical circuits. The number of inhibitory synapses made by CCK+/VGlut3+ basket cells and the inhibitory drive they exert on pyramidal cells are severely reduced in conditional mice lacking ErbB4. Developmental disruption of the connectivity of these cells diminishes the power of theta oscillations during exploratory behavior, disrupts spatial coding by place cells, and causes selective alterations in spatial learning and memory in adult mice. These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding information in hippocampus. 2017-04-10 2017-06 /pmc/articles/PMC5446788/ /pubmed/28394324 http://dx.doi.org/10.1038/nn.4544 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
del Pino, Isabel
Brotons-Mas, Jorge R.
Marques-Smith, André
Marighetto, Aline
Frick, Andreas
Marín, Oscar
Rico, Beatriz
Abnormal wiring of CCK+ basket cells disrupts spatial information coding
title Abnormal wiring of CCK+ basket cells disrupts spatial information coding
title_full Abnormal wiring of CCK+ basket cells disrupts spatial information coding
title_fullStr Abnormal wiring of CCK+ basket cells disrupts spatial information coding
title_full_unstemmed Abnormal wiring of CCK+ basket cells disrupts spatial information coding
title_short Abnormal wiring of CCK+ basket cells disrupts spatial information coding
title_sort abnormal wiring of cck+ basket cells disrupts spatial information coding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446788/
https://www.ncbi.nlm.nih.gov/pubmed/28394324
http://dx.doi.org/10.1038/nn.4544
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