TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B

Previous in vitro studies have indicated that tumor necrosis factor (TNF) activates amiloride-sensitive epithelial sodium channel (ENaC) current through its lectin-like (TIP) domain, since cyclic peptides mimicking the TIP domain (e.g., solnatide), showed ENaC-activating properties. In the current s...

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Detalles Bibliográficos
Autores principales: Willam, Anita, Aufy, Mohammed, Tzotzos, Susan, El-Malazi, Dina, Poser, Franziska, Wagner, Alina, Unterköfler, Birgit, Gurmani, Didja, Martan, David, Iqbal, Shahid Muhammad, Fischer, Bernhard, Fischer, Hendrik, Pietschmann, Helmut, Czikora, Istvan, Lucas, Rudolf, Lemmens-Gruber, Rosa, Shabbir, Waheed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447021/
https://www.ncbi.nlm.nih.gov/pubmed/28611771
http://dx.doi.org/10.3389/fimmu.2017.00601

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