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Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling

The process of gentamicin-induced hair cell damage includes the activation of oxidative stress processes. Sestrins, as stress-responsive proteins, protect cells against oxidative stress. Sestrins, particularly Sestrin-2, suppress excessive reactive oxygen species (ROS) accumulation and inhibit mamma...

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Detalles Bibliográficos
Autores principales:	Ebnoether, Eliane, Ramseier, Alessia, Cortada, Maurizio, Bodmer, Daniel, Levano-Huaman, Soledad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447131/ https://www.ncbi.nlm.nih.gov/pubmed/28580173 http://dx.doi.org/10.1038/cddiscovery.2017.24

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