Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation

Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation that can lead to their oncogenic transformation. Mediator(s) of cell–cell communication that brings about these pro-oncogenic pathologies has not been identified. We show here that cell-free chromatin (cfCh) r...

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Detalles Bibliográficos
Autores principales: Mittra, Indraneel, Samant, Urmila, Sharma, Suvarna, Raghuram, Gorantla V, Saha, Tannistha, Tidke, Pritishkumar, Pancholi, Namrata, Gupta, Deepika, Prasannan, Preeti, Gaikwad, Ashwini, Gardi, Nilesh, Chaubal, Rohan, Upadhyay, Pawan, Pal, Kavita, Rane, Bhagyeshri, Shaikh, Alfina, Salunkhe, Sameer, Dutt, Shilpee, Mishra, Pradyumna K, Khare, Naveen K, Nair, Naveen K, Dutt, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447133/
https://www.ncbi.nlm.nih.gov/pubmed/28580170
http://dx.doi.org/10.1038/cddiscovery.2017.15

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