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Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing

OBJECTIVE: To define genetic profiling of homologous recombination (HR) deficiency in Chinese ovarian cancer patients. METHODS: we have applied next-generation sequencing to detect deleterious mutations through all exons in 31 core HR genes. Paired whole blood and frozen tumor samples from 50 Chines...

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Detalles Bibliográficos
Autores principales:	Zhao, Qianying, Yang, Jiaxin, Li, Lei, Cao, Dongyan, Yu, Mei, Shen, Keng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447142/ https://www.ncbi.nlm.nih.gov/pubmed/28541631 http://dx.doi.org/10.3802/jgo.2017.28.e39

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