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Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study
OBJECTIVE: To assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment betw...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447148/ https://www.ncbi.nlm.nih.gov/pubmed/28541637 http://dx.doi.org/10.3802/jgo.2017.28.e49 |
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author | Sarı, Mustafa Erkan Meydanlı, Mehmet Mutlu Türkmen, Osman Cömert, Günsü Kimyon Turan, Ahmet Taner Karalök, Alper Şahin, Hanifi Haberal, Ali Kocaman, Eda Akbayır, Özgür Erdem, Baki Numanoğlu, Ceyhun Güngördük, Kemal Sancı, Muzaffer Gökçü, Mehmet Özgül, Nejat Salman, Mehmet Coşkun Boyraz, Gökhan Yüce, Kunter Güngör, Tayfun Taşkın, Salih Altın, Duygun Ortaç, Uğur Fırat Ayık, Hülya Aydın Şimşek, Tayup Arvas, Macit Ayhan, Ali |
author_facet | Sarı, Mustafa Erkan Meydanlı, Mehmet Mutlu Türkmen, Osman Cömert, Günsü Kimyon Turan, Ahmet Taner Karalök, Alper Şahin, Hanifi Haberal, Ali Kocaman, Eda Akbayır, Özgür Erdem, Baki Numanoğlu, Ceyhun Güngördük, Kemal Sancı, Muzaffer Gökçü, Mehmet Özgül, Nejat Salman, Mehmet Coşkun Boyraz, Gökhan Yüce, Kunter Güngör, Tayfun Taşkın, Salih Altın, Duygun Ortaç, Uğur Fırat Ayık, Hülya Aydın Şimşek, Tayup Arvas, Macit Ayhan, Ali |
author_sort | Sarı, Mustafa Erkan |
collection | PubMed |
description | OBJECTIVE: To assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment between 1997 and 2016 at 8 Gynecologic Oncology Centers. Demographic, clinicopathological, and survival data were collected. RESULTS: A total of 232 women with UCCC were identified. Of these, 53 (22.8%) had surgically-staged non-invasive UCCC. Twelve patients (22.6%) were upstaged at surgical assessment, including a 5.6% rate of lymphatic dissemination (3/53). Of those, 1 had stage IIIA, 1 had stage IIIC1, 1 had stage IIIC2, and 9 had stage IVB disease. Of the 9 women with stage IVB disease, 5 had isolated omental involvement indicating omentum as the most common metastatic site. UCCC limited only to the endometrium with no extra-uterine disease was confirmed in 41 women (73.3%) after surgical staging. Of those, 13 women (32%) were observed without adjuvant treatment whereas 28 patients (68%) underwent adjuvant therapy. The 5-year disease-free survival rates for patients with and without adjuvant treatment were 100.0% vs. 74.1%, respectively (p=0.060). CONCLUSION: Extra-uterine disease may occur in the absence of myometrial invasion (MMI), therefore comprehensive surgical staging including omentectomy should be the standard of care for women with UCCC regardless of the depth of MMI. Larger cohorts are needed in order to clarify the necessity of adjuvant treatment for women with UCCC truly confined to the endometrium. |
format | Online Article Text |
id | pubmed-5447148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-54471482017-07-01 Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study Sarı, Mustafa Erkan Meydanlı, Mehmet Mutlu Türkmen, Osman Cömert, Günsü Kimyon Turan, Ahmet Taner Karalök, Alper Şahin, Hanifi Haberal, Ali Kocaman, Eda Akbayır, Özgür Erdem, Baki Numanoğlu, Ceyhun Güngördük, Kemal Sancı, Muzaffer Gökçü, Mehmet Özgül, Nejat Salman, Mehmet Coşkun Boyraz, Gökhan Yüce, Kunter Güngör, Tayfun Taşkın, Salih Altın, Duygun Ortaç, Uğur Fırat Ayık, Hülya Aydın Şimşek, Tayup Arvas, Macit Ayhan, Ali J Gynecol Oncol Original Article OBJECTIVE: To assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment between 1997 and 2016 at 8 Gynecologic Oncology Centers. Demographic, clinicopathological, and survival data were collected. RESULTS: A total of 232 women with UCCC were identified. Of these, 53 (22.8%) had surgically-staged non-invasive UCCC. Twelve patients (22.6%) were upstaged at surgical assessment, including a 5.6% rate of lymphatic dissemination (3/53). Of those, 1 had stage IIIA, 1 had stage IIIC1, 1 had stage IIIC2, and 9 had stage IVB disease. Of the 9 women with stage IVB disease, 5 had isolated omental involvement indicating omentum as the most common metastatic site. UCCC limited only to the endometrium with no extra-uterine disease was confirmed in 41 women (73.3%) after surgical staging. Of those, 13 women (32%) were observed without adjuvant treatment whereas 28 patients (68%) underwent adjuvant therapy. The 5-year disease-free survival rates for patients with and without adjuvant treatment were 100.0% vs. 74.1%, respectively (p=0.060). CONCLUSION: Extra-uterine disease may occur in the absence of myometrial invasion (MMI), therefore comprehensive surgical staging including omentectomy should be the standard of care for women with UCCC regardless of the depth of MMI. Larger cohorts are needed in order to clarify the necessity of adjuvant treatment for women with UCCC truly confined to the endometrium. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2017-07 2017-05-15 /pmc/articles/PMC5447148/ /pubmed/28541637 http://dx.doi.org/10.3802/jgo.2017.28.e49 Text en Copyright © 2017. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sarı, Mustafa Erkan Meydanlı, Mehmet Mutlu Türkmen, Osman Cömert, Günsü Kimyon Turan, Ahmet Taner Karalök, Alper Şahin, Hanifi Haberal, Ali Kocaman, Eda Akbayır, Özgür Erdem, Baki Numanoğlu, Ceyhun Güngördük, Kemal Sancı, Muzaffer Gökçü, Mehmet Özgül, Nejat Salman, Mehmet Coşkun Boyraz, Gökhan Yüce, Kunter Güngör, Tayfun Taşkın, Salih Altın, Duygun Ortaç, Uğur Fırat Ayık, Hülya Aydın Şimşek, Tayup Arvas, Macit Ayhan, Ali Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study |
title | Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study |
title_full | Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study |
title_fullStr | Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study |
title_full_unstemmed | Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study |
title_short | Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study |
title_sort | prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a turkish gynecologic oncology group study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447148/ https://www.ncbi.nlm.nih.gov/pubmed/28541637 http://dx.doi.org/10.3802/jgo.2017.28.e49 |
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