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Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

BACKGROUND: Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whether this prionoid progression occurs via direct inter-neuronal transfer and, i...

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Detalles Bibliográficos
Autores principales:	Sorrentino, Zachary A., Brooks, Mieu M.T., Hudson, Vincent, Rutherford, Nicola J., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447308/ https://www.ncbi.nlm.nih.gov/pubmed/28552073 http://dx.doi.org/10.1186/s13024-017-0182-z

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