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The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation

Zoonotic Visceral Leishmaniasis (ZVL) is one of the world's deadliest and neglected infectious diseases, according to World Health Organization. This disease is one of major human and veterinary medical significance. The sandfly and the reservoir in urban areas remain among the major challenges...

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Autores principales: Shimozako, Helio Junji, Wu, Jianhong, Massad, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447317/
https://www.ncbi.nlm.nih.gov/pubmed/28588642
http://dx.doi.org/10.1155/2017/4797051
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author Shimozako, Helio Junji
Wu, Jianhong
Massad, Eduardo
author_facet Shimozako, Helio Junji
Wu, Jianhong
Massad, Eduardo
author_sort Shimozako, Helio Junji
collection PubMed
description Zoonotic Visceral Leishmaniasis (ZVL) is one of the world's deadliest and neglected infectious diseases, according to World Health Organization. This disease is one of major human and veterinary medical significance. The sandfly and the reservoir in urban areas remain among the major challenges for the control activities. In this paper, we evaluated five control strategies (positive dog elimination, insecticide impregnated dog collar, dog vaccination, dog treatment, and sandfly population control), considering disease control results and cost-effectiveness. We elaborated a mathematical model based on a set of differential equations in which three populations were represented (human, dog, and sandfly). Humans and dogs were divided into susceptible, latent, clinically ill, and recovery categories. Sandflies were divided into noninfected, infected, and infective. As the main conclusions, the insecticide impregnated dog collar was the strategy that presented the best combination between disease control and cost-effectiveness. But, depending on the population target, the control results and cost-effectiveness of each strategy may differ. More and detailed studies are needed, specially one which optimizes the control considering more than one strategy in activity.
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spelling pubmed-54473172017-06-06 The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation Shimozako, Helio Junji Wu, Jianhong Massad, Eduardo Comput Math Methods Med Research Article Zoonotic Visceral Leishmaniasis (ZVL) is one of the world's deadliest and neglected infectious diseases, according to World Health Organization. This disease is one of major human and veterinary medical significance. The sandfly and the reservoir in urban areas remain among the major challenges for the control activities. In this paper, we evaluated five control strategies (positive dog elimination, insecticide impregnated dog collar, dog vaccination, dog treatment, and sandfly population control), considering disease control results and cost-effectiveness. We elaborated a mathematical model based on a set of differential equations in which three populations were represented (human, dog, and sandfly). Humans and dogs were divided into susceptible, latent, clinically ill, and recovery categories. Sandflies were divided into noninfected, infected, and infective. As the main conclusions, the insecticide impregnated dog collar was the strategy that presented the best combination between disease control and cost-effectiveness. But, depending on the population target, the control results and cost-effectiveness of each strategy may differ. More and detailed studies are needed, specially one which optimizes the control considering more than one strategy in activity. Hindawi 2017 2017-05-15 /pmc/articles/PMC5447317/ /pubmed/28588642 http://dx.doi.org/10.1155/2017/4797051 Text en Copyright © 2017 Helio Junji Shimozako et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shimozako, Helio Junji
Wu, Jianhong
Massad, Eduardo
The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation
title The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation
title_full The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation
title_fullStr The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation
title_full_unstemmed The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation
title_short The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation
title_sort preventive control of zoonotic visceral leishmaniasis: efficacy and economic evaluation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447317/
https://www.ncbi.nlm.nih.gov/pubmed/28588642
http://dx.doi.org/10.1155/2017/4797051
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