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HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer

T cell receptor (TCR)-gene-modified T cells for adoptive cell transfer can mediate objective clinical responses in melanoma and other malignancies. When introducing a second TCR, mispairing between the endogenous and introduced α and β TCR chains limits expression of the introduced TCR, which can re...

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Detalles Bibliográficos
Autores principales:	Foley, Kendra C., Spear, Timothy T., Murray, David C., Nagato, Kaoru, Garrett-Mayer, Elizabeth, Nishimura, Michael I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447397/ https://www.ncbi.nlm.nih.gov/pubmed/28573185 http://dx.doi.org/10.1016/j.omto.2017.05.004

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