Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme

In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with the chlorosulfonic acid pyridine method. The inhibitory effect of Sargassum fusiforme polysaccharides a...

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Detalles Bibliográficos
Autores principales: Yu, Miao, Ji, Yubin, Qi, Zheng, Cui, Di, Xin, Guosong, Wang, Bing, Cao, Yue, Wang, Dandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447403/
https://www.ncbi.nlm.nih.gov/pubmed/28579876
http://dx.doi.org/10.1016/j.jsps.2017.04.007
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author Yu, Miao
Ji, Yubin
Qi, Zheng
Cui, Di
Xin, Guosong
Wang, Bing
Cao, Yue
Wang, Dandan
author_facet Yu, Miao
Ji, Yubin
Qi, Zheng
Cui, Di
Xin, Guosong
Wang, Bing
Cao, Yue
Wang, Dandan
author_sort Yu, Miao
collection PubMed
description In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with the chlorosulfonic acid pyridine method. The inhibitory effect of Sargassum fusiforme polysaccharides and the application of MTT assay before and after chemical modification on the proliferation of hepatocellular carcinoma HepG-2 cells in vitro were studied. Sulfated polysaccharide from sargassum fusiforme DS is 0.803. The modified polysaccharide has certain inhibitory effect on HepG-2 cells, and its inhibition on the cells growth has improved compared with the original SFPs. The sulfated polysaccharide from Sargassum fusiforme has the ability to enhance anti-tumor activities.
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spelling pubmed-54474032017-06-02 Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme Yu, Miao Ji, Yubin Qi, Zheng Cui, Di Xin, Guosong Wang, Bing Cao, Yue Wang, Dandan Saudi Pharm J Article In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with the chlorosulfonic acid pyridine method. The inhibitory effect of Sargassum fusiforme polysaccharides and the application of MTT assay before and after chemical modification on the proliferation of hepatocellular carcinoma HepG-2 cells in vitro were studied. Sulfated polysaccharide from sargassum fusiforme DS is 0.803. The modified polysaccharide has certain inhibitory effect on HepG-2 cells, and its inhibition on the cells growth has improved compared with the original SFPs. The sulfated polysaccharide from Sargassum fusiforme has the ability to enhance anti-tumor activities. Elsevier 2017-05 2017-04-28 /pmc/articles/PMC5447403/ /pubmed/28579876 http://dx.doi.org/10.1016/j.jsps.2017.04.007 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of King Saud University. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yu, Miao
Ji, Yubin
Qi, Zheng
Cui, Di
Xin, Guosong
Wang, Bing
Cao, Yue
Wang, Dandan
Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme
title Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme
title_full Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme
title_fullStr Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme
title_full_unstemmed Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme
title_short Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme
title_sort anti-tumor activity of sulfated polysaccharides from sargassum fusiforme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447403/
https://www.ncbi.nlm.nih.gov/pubmed/28579876
http://dx.doi.org/10.1016/j.jsps.2017.04.007
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