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The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447443/ https://www.ncbi.nlm.nih.gov/pubmed/28579909 http://dx.doi.org/10.1016/j.jsps.2017.05.001 |
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author | Zhang, Xiangcheng Shang, Futai Hui, Liangliang Zang, Kui Sun, Gengyun |
author_facet | Zhang, Xiangcheng Shang, Futai Hui, Liangliang Zang, Kui Sun, Gengyun |
author_sort | Zhang, Xiangcheng |
collection | PubMed |
description | For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected and LPS was injected 30 min later. The data suggested Met can reduce release of inflammatory cytokines and bronchoalveolar lavage fluid (BALF) protein expression, reduce lung wet/dry ratio, and significantly improve LPS-induced lung destruction during ALI. In addition, Met inhibits LPS-induced neutrophil and macrophage infiltration, reduces MPO activity, and promotes AMPK-α1 expression in lung tissues. Our data suggested that metformin alleviates capillary injury during ALI via AMPK-α1. |
format | Online Article Text |
id | pubmed-5447443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54474432017-06-02 The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism Zhang, Xiangcheng Shang, Futai Hui, Liangliang Zang, Kui Sun, Gengyun Saudi Pharm J Article For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected and LPS was injected 30 min later. The data suggested Met can reduce release of inflammatory cytokines and bronchoalveolar lavage fluid (BALF) protein expression, reduce lung wet/dry ratio, and significantly improve LPS-induced lung destruction during ALI. In addition, Met inhibits LPS-induced neutrophil and macrophage infiltration, reduces MPO activity, and promotes AMPK-α1 expression in lung tissues. Our data suggested that metformin alleviates capillary injury during ALI via AMPK-α1. Elsevier 2017-05 2017-05-10 /pmc/articles/PMC5447443/ /pubmed/28579909 http://dx.doi.org/10.1016/j.jsps.2017.05.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Zhang, Xiangcheng Shang, Futai Hui, Liangliang Zang, Kui Sun, Gengyun The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
title | The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
title_full | The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
title_fullStr | The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
title_full_unstemmed | The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
title_short | The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
title_sort | alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447443/ https://www.ncbi.nlm.nih.gov/pubmed/28579909 http://dx.doi.org/10.1016/j.jsps.2017.05.001 |
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