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The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism

For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected...

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Autores principales: Zhang, Xiangcheng, Shang, Futai, Hui, Liangliang, Zang, Kui, Sun, Gengyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447443/
https://www.ncbi.nlm.nih.gov/pubmed/28579909
http://dx.doi.org/10.1016/j.jsps.2017.05.001
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author Zhang, Xiangcheng
Shang, Futai
Hui, Liangliang
Zang, Kui
Sun, Gengyun
author_facet Zhang, Xiangcheng
Shang, Futai
Hui, Liangliang
Zang, Kui
Sun, Gengyun
author_sort Zhang, Xiangcheng
collection PubMed
description For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected and LPS was injected 30 min later. The data suggested Met can reduce release of inflammatory cytokines and bronchoalveolar lavage fluid (BALF) protein expression, reduce lung wet/dry ratio, and significantly improve LPS-induced lung destruction during ALI. In addition, Met inhibits LPS-induced neutrophil and macrophage infiltration, reduces MPO activity, and promotes AMPK-α1 expression in lung tissues. Our data suggested that metformin alleviates capillary injury during ALI via AMPK-α1.
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spelling pubmed-54474432017-06-02 The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism Zhang, Xiangcheng Shang, Futai Hui, Liangliang Zang, Kui Sun, Gengyun Saudi Pharm J Article For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected and LPS was injected 30 min later. The data suggested Met can reduce release of inflammatory cytokines and bronchoalveolar lavage fluid (BALF) protein expression, reduce lung wet/dry ratio, and significantly improve LPS-induced lung destruction during ALI. In addition, Met inhibits LPS-induced neutrophil and macrophage infiltration, reduces MPO activity, and promotes AMPK-α1 expression in lung tissues. Our data suggested that metformin alleviates capillary injury during ALI via AMPK-α1. Elsevier 2017-05 2017-05-10 /pmc/articles/PMC5447443/ /pubmed/28579909 http://dx.doi.org/10.1016/j.jsps.2017.05.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Xiangcheng
Shang, Futai
Hui, Liangliang
Zang, Kui
Sun, Gengyun
The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
title The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
title_full The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
title_fullStr The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
title_full_unstemmed The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
title_short The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
title_sort alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447443/
https://www.ncbi.nlm.nih.gov/pubmed/28579909
http://dx.doi.org/10.1016/j.jsps.2017.05.001
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