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Genetic Testing for Opioid Pain Management: A Primer

Patients see their primary care physicians (PCPs) for a variety of medical conditions, chronic pain being one of the most common. An increased use of prescription medications (especially opioids) has led to an increase in adverse drug reactions and has heightened our awareness of the variability in...

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Detalles Bibliográficos
Autores principales: Agarwal, Deepti, Udoji, Mercy A., Trescot, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447546/
https://www.ncbi.nlm.nih.gov/pubmed/28409480
http://dx.doi.org/10.1007/s40122-017-0069-2
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author Agarwal, Deepti
Udoji, Mercy A.
Trescot, Andrea
author_facet Agarwal, Deepti
Udoji, Mercy A.
Trescot, Andrea
author_sort Agarwal, Deepti
collection PubMed
description Patients see their primary care physicians (PCPs) for a variety of medical conditions, chronic pain being one of the most common. An increased use of prescription medications (especially opioids) has led to an increase in adverse drug reactions and has heightened our awareness of the variability in response to medications. Opioids and other pain adjuvants are widely used, and drug–drug interactions involving these analgesics can be problematic and potentially lethal. Pharmacogenetics has improved our understanding of drug efficacy and response, opened doors to individual tailoring of medical management, and created a series of ethical and economic considerations. Since it is a relatively new field, genetic testing has not been fully integrated into the primary care setting. The purpose of this paper is to review the metabolism of commonly prescribed opioids, discuss the economic and ethical issues, and provide PCPs with an understanding of how to incorporate genetic testing into routine use to improve clinical practice and patient management.
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spelling pubmed-54475462017-06-13 Genetic Testing for Opioid Pain Management: A Primer Agarwal, Deepti Udoji, Mercy A. Trescot, Andrea Pain Ther Commentary Patients see their primary care physicians (PCPs) for a variety of medical conditions, chronic pain being one of the most common. An increased use of prescription medications (especially opioids) has led to an increase in adverse drug reactions and has heightened our awareness of the variability in response to medications. Opioids and other pain adjuvants are widely used, and drug–drug interactions involving these analgesics can be problematic and potentially lethal. Pharmacogenetics has improved our understanding of drug efficacy and response, opened doors to individual tailoring of medical management, and created a series of ethical and economic considerations. Since it is a relatively new field, genetic testing has not been fully integrated into the primary care setting. The purpose of this paper is to review the metabolism of commonly prescribed opioids, discuss the economic and ethical issues, and provide PCPs with an understanding of how to incorporate genetic testing into routine use to improve clinical practice and patient management. Springer Healthcare 2017-04-13 2017-06 /pmc/articles/PMC5447546/ /pubmed/28409480 http://dx.doi.org/10.1007/s40122-017-0069-2 Text en © The Author(s) 2017 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Commentary
Agarwal, Deepti
Udoji, Mercy A.
Trescot, Andrea
Genetic Testing for Opioid Pain Management: A Primer
title Genetic Testing for Opioid Pain Management: A Primer
title_full Genetic Testing for Opioid Pain Management: A Primer
title_fullStr Genetic Testing for Opioid Pain Management: A Primer
title_full_unstemmed Genetic Testing for Opioid Pain Management: A Primer
title_short Genetic Testing for Opioid Pain Management: A Primer
title_sort genetic testing for opioid pain management: a primer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447546/
https://www.ncbi.nlm.nih.gov/pubmed/28409480
http://dx.doi.org/10.1007/s40122-017-0069-2
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