Why We should Assess Patients’ Expectations in Clinical Trials

Most of the analgesic clinical trials have failed to succeed over the past years because of the occurrence of large placebo responses. Patients’ expectations about the therapeutic benefit represent a major determinant of the placebo response. Therefore, assessing patients’ expectations should become...

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Detalles Bibliográficos
Autores principales: Frisaldi, Elisa, Shaibani, Aziz, Benedetti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447548/
https://www.ncbi.nlm.nih.gov/pubmed/28477082
http://dx.doi.org/10.1007/s40122-017-0071-8
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author Frisaldi, Elisa
Shaibani, Aziz
Benedetti, Fabrizio
author_facet Frisaldi, Elisa
Shaibani, Aziz
Benedetti, Fabrizio
author_sort Frisaldi, Elisa
collection PubMed
description Most of the analgesic clinical trials have failed to succeed over the past years because of the occurrence of large placebo responses. Patients’ expectations about the therapeutic benefit represent a major determinant of the placebo response. Therefore, assessing patients’ expectations should become the rule in any clinical trial. This would allow us to better interpret therapeutic outcomes when comparing placebo and verum groups.
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spelling pubmed-54475482017-06-13 Why We should Assess Patients’ Expectations in Clinical Trials Frisaldi, Elisa Shaibani, Aziz Benedetti, Fabrizio Pain Ther Commentary Most of the analgesic clinical trials have failed to succeed over the past years because of the occurrence of large placebo responses. Patients’ expectations about the therapeutic benefit represent a major determinant of the placebo response. Therefore, assessing patients’ expectations should become the rule in any clinical trial. This would allow us to better interpret therapeutic outcomes when comparing placebo and verum groups. Springer Healthcare 2017-05-05 2017-06 /pmc/articles/PMC5447548/ /pubmed/28477082 http://dx.doi.org/10.1007/s40122-017-0071-8 Text en © The Author(s) 2017 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Commentary
Frisaldi, Elisa
Shaibani, Aziz
Benedetti, Fabrizio
Why We should Assess Patients’ Expectations in Clinical Trials
title Why We should Assess Patients’ Expectations in Clinical Trials
title_full Why We should Assess Patients’ Expectations in Clinical Trials
title_fullStr Why We should Assess Patients’ Expectations in Clinical Trials
title_full_unstemmed Why We should Assess Patients’ Expectations in Clinical Trials
title_short Why We should Assess Patients’ Expectations in Clinical Trials
title_sort why we should assess patients’ expectations in clinical trials
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447548/
https://www.ncbi.nlm.nih.gov/pubmed/28477082
http://dx.doi.org/10.1007/s40122-017-0071-8
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