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Cortical gyrification is abnormal in children with prenatal alcohol exposure
OBJECTIVES: Prenatal alcohol exposure (PAE) adversely affects early brain development. Previous studies have shown a wide range of structural and functional abnormalities in children and adolescents with PAE. The current study adds to the existing literature specifically on cortical development by e...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447653/ https://www.ncbi.nlm.nih.gov/pubmed/28580296 http://dx.doi.org/10.1016/j.nicl.2017.05.015 |
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author | Hendrickson, Timothy J. Mueller, Bryon A. Sowell, Elizabeth R. Mattson, Sarah N. Coles, Claire D. Kable, Julie A. Jones, Kenneth L. Boys, Christopher J. Lim, Kelvin O. Riley, Edward P. Wozniak, Jeffrey R. |
author_facet | Hendrickson, Timothy J. Mueller, Bryon A. Sowell, Elizabeth R. Mattson, Sarah N. Coles, Claire D. Kable, Julie A. Jones, Kenneth L. Boys, Christopher J. Lim, Kelvin O. Riley, Edward P. Wozniak, Jeffrey R. |
author_sort | Hendrickson, Timothy J. |
collection | PubMed |
description | OBJECTIVES: Prenatal alcohol exposure (PAE) adversely affects early brain development. Previous studies have shown a wide range of structural and functional abnormalities in children and adolescents with PAE. The current study adds to the existing literature specifically on cortical development by examining cortical gyrification in a large sample of children with PAE compared to controls. Relationships between cortical development and intellectual functioning are also examined. EXPERIMENTAL DESIGN: Included were 92 children with PAE and 83 controls ages 9–16 from four sites in the Collaborative Initiative on FASD (CIFASD). All PAE participants had documented heavy PAE. All underwent a formal evaluation of physical anomalies and dysmorphic facial features. MRI data were collected using modified matched protocols on three platforms (Siemens, GE, and Philips). Cortical gyrification was examined using a semi-automated procedure. PRINCIPAL OBSERVATIONS: Whole brain group comparisons using Monte Carlo z-simulation for multiple comparisons showed significantly lower cortical gyrification across a large proportion of the cerebral cortex amongst PAE compared to controls. Whole brain comparisons and ROI based analyses showed strong positive correlations between cortical gyrification and IQ (i.e. less developed cortex was associated with lower IQ). CONCLUSIONS: Abnormalities in cortical development were seen across the brain in children with PAE compared to controls. Cortical gyrification and IQ were strongly correlated, suggesting that examining mechanisms by which alcohol disrupts cortical formation may yield clinically relevant insights and potential directions for early intervention. |
format | Online Article Text |
id | pubmed-5447653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54476532017-06-02 Cortical gyrification is abnormal in children with prenatal alcohol exposure Hendrickson, Timothy J. Mueller, Bryon A. Sowell, Elizabeth R. Mattson, Sarah N. Coles, Claire D. Kable, Julie A. Jones, Kenneth L. Boys, Christopher J. Lim, Kelvin O. Riley, Edward P. Wozniak, Jeffrey R. Neuroimage Clin Regular Article OBJECTIVES: Prenatal alcohol exposure (PAE) adversely affects early brain development. Previous studies have shown a wide range of structural and functional abnormalities in children and adolescents with PAE. The current study adds to the existing literature specifically on cortical development by examining cortical gyrification in a large sample of children with PAE compared to controls. Relationships between cortical development and intellectual functioning are also examined. EXPERIMENTAL DESIGN: Included were 92 children with PAE and 83 controls ages 9–16 from four sites in the Collaborative Initiative on FASD (CIFASD). All PAE participants had documented heavy PAE. All underwent a formal evaluation of physical anomalies and dysmorphic facial features. MRI data were collected using modified matched protocols on three platforms (Siemens, GE, and Philips). Cortical gyrification was examined using a semi-automated procedure. PRINCIPAL OBSERVATIONS: Whole brain group comparisons using Monte Carlo z-simulation for multiple comparisons showed significantly lower cortical gyrification across a large proportion of the cerebral cortex amongst PAE compared to controls. Whole brain comparisons and ROI based analyses showed strong positive correlations between cortical gyrification and IQ (i.e. less developed cortex was associated with lower IQ). CONCLUSIONS: Abnormalities in cortical development were seen across the brain in children with PAE compared to controls. Cortical gyrification and IQ were strongly correlated, suggesting that examining mechanisms by which alcohol disrupts cortical formation may yield clinically relevant insights and potential directions for early intervention. Elsevier 2017-05-22 /pmc/articles/PMC5447653/ /pubmed/28580296 http://dx.doi.org/10.1016/j.nicl.2017.05.015 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Hendrickson, Timothy J. Mueller, Bryon A. Sowell, Elizabeth R. Mattson, Sarah N. Coles, Claire D. Kable, Julie A. Jones, Kenneth L. Boys, Christopher J. Lim, Kelvin O. Riley, Edward P. Wozniak, Jeffrey R. Cortical gyrification is abnormal in children with prenatal alcohol exposure |
title | Cortical gyrification is abnormal in children with prenatal alcohol exposure |
title_full | Cortical gyrification is abnormal in children with prenatal alcohol exposure |
title_fullStr | Cortical gyrification is abnormal in children with prenatal alcohol exposure |
title_full_unstemmed | Cortical gyrification is abnormal in children with prenatal alcohol exposure |
title_short | Cortical gyrification is abnormal in children with prenatal alcohol exposure |
title_sort | cortical gyrification is abnormal in children with prenatal alcohol exposure |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447653/ https://www.ncbi.nlm.nih.gov/pubmed/28580296 http://dx.doi.org/10.1016/j.nicl.2017.05.015 |
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