Cargando…

Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran

Background: Patients undergoing open heart surgery have a relatively high risk of acquiring nosocomial infections. The development of antibiotic-resistant infections is associated with prolonged hospital stays and mortalities. Objectives: The present study was conducted to investigate nosocomial inf...

Descripción completa

Detalles Bibliográficos
Autores principales: Heydarpour, Fatemeh, Rahmani, Youssef, Heydarpour, Behzad, Asadmobini, Atefeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447783/
https://www.ncbi.nlm.nih.gov/pubmed/28584733
http://dx.doi.org/10.3205/dgkh000292
_version_ 1783239422348623872
author Heydarpour, Fatemeh
Rahmani, Youssef
Heydarpour, Behzad
Asadmobini, Atefeh
author_facet Heydarpour, Fatemeh
Rahmani, Youssef
Heydarpour, Behzad
Asadmobini, Atefeh
author_sort Heydarpour, Fatemeh
collection PubMed
description Background: Patients undergoing open heart surgery have a relatively high risk of acquiring nosocomial infections. The development of antibiotic-resistant infections is associated with prolonged hospital stays and mortalities. Objectives: The present study was conducted to investigate nosocomial infections and the antibiotic resistance pattern in bacteria causing these infections in open heart surgery patients at Imam Ali Hospital in Kermanshah in the west of Iran over a 4-year period from March 2011 to March 2014. Materials and methods: The present cross-sectional study was conducted on 135 cases of nosocomial infection among open heart surgery patients. The demographic characteristics and the risk factors of each case of infection were recorded. The antibiotic susceptibility test was carried out using the Minimum Inhibitory Concentration (MIC) method based on the Clinical and Laboratory Standards Institute (CLSI) protocol. The data collected were then analyzed in SPSS-16. Results: Out of the 6,000 patients who underwent open heart surgery during this 4-year period at the selected hospital, nosocomial infections developed in 135 patients (2.25%), 59.3% of whom were female and 40.7% male. Surgery site infection (SSI), pneumonia (PNEU), urinary tract infection (UTI) and blood stream infection (BSI) affected 52.6%, 37%, 9.6% and 0.8% of the cases, respectively. E.coli, Klebsiella spp. and S. aureus were the most common bacteria causing the nosocomial infections. E. coli was most frequently resistant to imipenem (23.3%) Klebsiella spp. to gentamicin (38.5%) S. aureus to co-trimoxazole (54.2%). Conclusion: SSI had a high prevalence in this study. Further studies should therefore be conducted to examine the risk factors associated with SSI in open heart surgery. Various studies have shown that antibiotic resistance patterns are different in different regions. Finding a definitive treatment therefore requires an antibiogram.
format Online
Article
Text
id pubmed-5447783
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher German Medical Science GMS Publishing House
record_format MEDLINE/PubMed
spelling pubmed-54477832017-06-05 Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran Heydarpour, Fatemeh Rahmani, Youssef Heydarpour, Behzad Asadmobini, Atefeh GMS Hyg Infect Control Article Background: Patients undergoing open heart surgery have a relatively high risk of acquiring nosocomial infections. The development of antibiotic-resistant infections is associated with prolonged hospital stays and mortalities. Objectives: The present study was conducted to investigate nosocomial infections and the antibiotic resistance pattern in bacteria causing these infections in open heart surgery patients at Imam Ali Hospital in Kermanshah in the west of Iran over a 4-year period from March 2011 to March 2014. Materials and methods: The present cross-sectional study was conducted on 135 cases of nosocomial infection among open heart surgery patients. The demographic characteristics and the risk factors of each case of infection were recorded. The antibiotic susceptibility test was carried out using the Minimum Inhibitory Concentration (MIC) method based on the Clinical and Laboratory Standards Institute (CLSI) protocol. The data collected were then analyzed in SPSS-16. Results: Out of the 6,000 patients who underwent open heart surgery during this 4-year period at the selected hospital, nosocomial infections developed in 135 patients (2.25%), 59.3% of whom were female and 40.7% male. Surgery site infection (SSI), pneumonia (PNEU), urinary tract infection (UTI) and blood stream infection (BSI) affected 52.6%, 37%, 9.6% and 0.8% of the cases, respectively. E.coli, Klebsiella spp. and S. aureus were the most common bacteria causing the nosocomial infections. E. coli was most frequently resistant to imipenem (23.3%) Klebsiella spp. to gentamicin (38.5%) S. aureus to co-trimoxazole (54.2%). Conclusion: SSI had a high prevalence in this study. Further studies should therefore be conducted to examine the risk factors associated with SSI in open heart surgery. Various studies have shown that antibiotic resistance patterns are different in different regions. Finding a definitive treatment therefore requires an antibiogram. German Medical Science GMS Publishing House 2017-05-24 /pmc/articles/PMC5447783/ /pubmed/28584733 http://dx.doi.org/10.3205/dgkh000292 Text en Copyright © 2017 Heydarpour et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Heydarpour, Fatemeh
Rahmani, Youssef
Heydarpour, Behzad
Asadmobini, Atefeh
Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran
title Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran
title_full Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran
title_fullStr Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran
title_full_unstemmed Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran
title_short Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran
title_sort nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at imam ali hospital in kermanshah, iran
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447783/
https://www.ncbi.nlm.nih.gov/pubmed/28584733
http://dx.doi.org/10.3205/dgkh000292
work_keys_str_mv AT heydarpourfatemeh nosocomialinfectionsandantibioticresistancepatterninopenheartsurgerypatientsatimamalihospitalinkermanshahiran
AT rahmaniyoussef nosocomialinfectionsandantibioticresistancepatterninopenheartsurgerypatientsatimamalihospitalinkermanshahiran
AT heydarpourbehzad nosocomialinfectionsandantibioticresistancepatterninopenheartsurgerypatientsatimamalihospitalinkermanshahiran
AT asadmobiniatefeh nosocomialinfectionsandantibioticresistancepatterninopenheartsurgerypatientsatimamalihospitalinkermanshahiran