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Neuronal Migration and AUTS2 Syndrome
Neuronal migration is one of the pivotal steps to form a functional brain, and disorganization of this process is believed to underlie the pathology of psychiatric disorders including schizophrenia, autism spectrum disorders (ASD) and epilepsy. However, it is not clear how abnormal neuronal migratio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447936/ https://www.ncbi.nlm.nih.gov/pubmed/28505103 http://dx.doi.org/10.3390/brainsci7050054 |
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author | Hori, Kei Hoshino, Mikio |
author_facet | Hori, Kei Hoshino, Mikio |
author_sort | Hori, Kei |
collection | PubMed |
description | Neuronal migration is one of the pivotal steps to form a functional brain, and disorganization of this process is believed to underlie the pathology of psychiatric disorders including schizophrenia, autism spectrum disorders (ASD) and epilepsy. However, it is not clear how abnormal neuronal migration causes mental dysfunction. Recently, a key gene for various psychiatric diseases, the Autism susceptibility candidate 2 (AUTS2), has been shown to regulate neuronal migration, which gives new insight into understanding this question. Interestingly, the AUTS2 protein has dual functions: Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1). In this review, we discuss AUTS2 from the viewpoint of human genetics, molecular function, brain development, and behavior in animal models, focusing on its role in neuronal migration. |
format | Online Article Text |
id | pubmed-5447936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54479362017-05-30 Neuronal Migration and AUTS2 Syndrome Hori, Kei Hoshino, Mikio Brain Sci Review Neuronal migration is one of the pivotal steps to form a functional brain, and disorganization of this process is believed to underlie the pathology of psychiatric disorders including schizophrenia, autism spectrum disorders (ASD) and epilepsy. However, it is not clear how abnormal neuronal migration causes mental dysfunction. Recently, a key gene for various psychiatric diseases, the Autism susceptibility candidate 2 (AUTS2), has been shown to regulate neuronal migration, which gives new insight into understanding this question. Interestingly, the AUTS2 protein has dual functions: Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1). In this review, we discuss AUTS2 from the viewpoint of human genetics, molecular function, brain development, and behavior in animal models, focusing on its role in neuronal migration. MDPI 2017-05-14 /pmc/articles/PMC5447936/ /pubmed/28505103 http://dx.doi.org/10.3390/brainsci7050054 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hori, Kei Hoshino, Mikio Neuronal Migration and AUTS2 Syndrome |
title | Neuronal Migration and AUTS2 Syndrome |
title_full | Neuronal Migration and AUTS2 Syndrome |
title_fullStr | Neuronal Migration and AUTS2 Syndrome |
title_full_unstemmed | Neuronal Migration and AUTS2 Syndrome |
title_short | Neuronal Migration and AUTS2 Syndrome |
title_sort | neuronal migration and auts2 syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447936/ https://www.ncbi.nlm.nih.gov/pubmed/28505103 http://dx.doi.org/10.3390/brainsci7050054 |
work_keys_str_mv | AT horikei neuronalmigrationandauts2syndrome AT hoshinomikio neuronalmigrationandauts2syndrome |