Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication

In fission yeast, the small, intrinsically disordered protein S-phase delaying protein 1 (Spd1) blocks DNA replication and causes checkpoint activation at least in part, by inhibiting the enzyme ribonucleotide reductase, which is responsible for the synthesis of DNA building blocks. The CRL4(Cdt2) E...

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Detalles Bibliográficos
Autores principales: Fleck, Oliver, Fahnøe, Ulrik, Løvschal, Katrine Vyff, Gasasira, Marie-Fabrice Uwamahoro, Marinova, Irina N., Kragelund, Birthe B., Carr, Antony M., Hartsuiker, Edgar, Holmberg, Christian, Nielsen, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448002/
https://www.ncbi.nlm.nih.gov/pubmed/28441348
http://dx.doi.org/10.3390/genes8050128

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